Glycine, N-[(phenylmethoxy)carbonyl]-, 2-iodoethyl ester

Base Information

• Chemical Name: Glycine, N-[(phenylmethoxy)carbonyl]-, 2-iodoethyl ester
• CAS No.: 156539-07-0
• Molecular Formula: C12H14INO4
• Molecular Weight: 363.152
• Mol file: 156539-07-0.mol

Synonyms:

Chemical Property of Glycine, N-[(phenylmethoxy)carbonyl]-, 2-iodoethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Glycine, N-[(phenylmethoxy)carbonyl]-, 2-iodoethyl ester

There total 2 articles about Glycine, N-[(phenylmethoxy)carbonyl]-, 2-iodoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-<(Phenylmethoxy)carbonyl>glycine 2-bromoethyl ester (156539-01-4) → glycine N-<(phenylmethoxy)carbonyl>glycine 2-iodoethyl ester (156539-07-0)

Guidance literature:

With sodium iodide; In acetone; for 7h; Heating;

DOI:10.1021/jo00087a053

Reference yield: 66.0%

Iodoethanol (624-76-0) + N-(Benzyloxycarbonyl)glycine (1138-80-3) → glycine N-<(phenylmethoxy)carbonyl>glycine 2-iodoethyl ester (156539-07-0)

Guidance literature:

With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In chloroform; for 12h; Ambient temperature;

DOI:10.1021/jo00126a080

Reference yield: 89.0%

glycine N-<(phenylmethoxy)carbonyl>glycine 2-iodoethyl ester (156539-07-0) → N-(Benzyloxycarbonyl)glycine (1138-80-3)

Guidance literature:

With samarium diiodide; In tetrahydrofuran; at 40 ℃; for 8h;

DOI:10.1021/jo00087a053

upstream raw materials:

N-<(Phenylmethoxy)carbonyl>glycine 2-bromoethyl ester

Iodoethanol

N-(Benzyloxycarbonyl)glycine

Downstream raw materials:

N-(Benzyloxycarbonyl)glycine

Refernces

• 1、 Pearson, Anthony J.,Lee, Kieseung. "Some Studies on the Use of 2-Bromoethyl and 2-Iodoethyl Ester Blocking Groups in Peptide Synthesis: Samarium Diiodide-Mediated Deprotection". . p. 2257 - 2260. Retrieved 2007/10/02.