Technology Process of 2-Butenoic acid, 2-methyl-4-oxo-4-phenyl-, methyl ester, (E)-
There total 10 articles about 2-Butenoic acid, 2-methyl-4-oxo-4-phenyl-, methyl ester, (E)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
dimethyl (2-oxo-2-phenylethyl)phosphonate;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -20 ℃;
for 0.5h;
Inert atmosphere;
pyruvic acid methyl ester;
In
tetrahydrofuran; hexane;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/acs.orglett.0c01618
- Guidance literature:
-
In
chloroform;
at 20 ℃;
for 48h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium diisopropyl amide / hexane; tetrahydrofuran / -20 - 20 °C / Inert atmosphere
2.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -20 °C / Inert atmosphere
2.2: 1 h / 20 °C / Inert atmosphere
With
n-butyllithium; lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
DOI:10.1021/acs.orglett.0c01618
