5-PHENYLNICOTINIC ACID

Base Information

• Chemical Name: 5-PHENYLNICOTINIC ACID
• CAS No.: 10177-12-5
• Molecular Formula: C12H9NO2
• Molecular Weight: 199.209
• Hs Code.: 2933399090
• Mol file: 10177-12-5.mol

Synonyms:Nicotinicacid, 5-phenyl- (6CI,7CI,8CI);5-Phenylnicotinic acid;5-Phenylpyridine-3-carboxylic acid;NSC 404257;AKOS BAR-0484;

Chemical Property of 5-PHENYLNICOTINIC ACID

Chemical Property:

• Vapor Pressure: 8.31E-08mmHg at 25°C
• Melting Point: 260 °C
• Refractive Index: 1.613
• Boiling Point: 420.1 °C at 760 mmHg
• Flash Point: 207.8 °C
• PSA: 50.19000
• Density: 1.241 g/cm³
• LogP: 2.44680
• Storage Temp.: Room temperature.

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Phenylnicotinicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-PHENYLNICOTINIC ACID

There total 6 articles about 5-PHENYLNICOTINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

5-bromo-3-pyridinecarboxylic acid (20826-04-4) + phenylboronic acid (98-80-6) → 5-phenylnicotinic acid (10177-12-5)

Guidance literature:

With potassium carbonate; In water; N,N-dimethyl-formamide; at 70 ℃; for 1.66667h;

DOI:10.1039/c6ra21223a

Reference yield: 78.0%

5-phenyl-3-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)pyridine (1254929-25-3) → 5-phenylnicotinic acid (10177-12-5)

Guidance literature:

With hydrogenchloride; In water; acetic acid; at 95 ℃; for 36h;

DOI:10.1021/jm1007209

Reference yield:

3-methyl-5-phenylpyridine (10477-94-8) → 5-phenylnicotinic acid (10177-12-5)

Guidance literature:

With potassium hydroxide; potassium permanganate;

DOI:10.1021/ja01595a057

upstream raw materials:

3-methyl-5-phenylpyridine

5-bromo-3-pyridinecarboxylic acid

tributylphenylstannane

phenylacetaldehyde

Downstream raw materials:

C₁₂H₈ClNO

5-phenylnicotinic acid ethyl ester

C₂₀H₁₇N₃O₂S

ethyl-5-phenylpyridin-3-yl carbamate

Refernces

• 1、 Golestanzadeh, Mohsen,Naeimi, Hossein. "Palladium decorated on a new dendritic complex with nitrogen ligation grafted to graphene oxide: Fabrication, characterization, and catalytic application". . p. 27560 - 27573. Retrieved 2019.
• 2、 Chamoin, Sylvie,Houldsworth, Stephen,Snieckus, Victor. "The stille cross coupling reactions on solid support. Link to solution phase directed ortho metalation. An ester linker approach to styryl, biaryl and heterobiaryl carboxylic acids". . p. 4175 - 4178. Retrieved 1998.