5-METHOXY-BENZOFURAN-3-ONE

Base Information

• Chemical Name: 5-METHOXY-BENZOFURAN-3-ONE
• CAS No.: 39581-55-0
• Molecular Formula: C9H8 O3
• Molecular Weight: 164.161
• Hs Code.: 2932999099
• Mol file: 39581-55-0.mol

Synonyms:2,3-Dihydro-5-methoxybenzo[b]furan-3-one;5-Methoxy-3(2H)-benzofuranone; 5-Methoxy-3-benzo[b]furanone;5-Methoxybenzofuran-3(2H)-one; NSC 404884

Chemical Property of 5-METHOXY-BENZOFURAN-3-ONE

Chemical Property:

• Vapor Pressure: 0.0012mmHg at 25°C
• Boiling Point: 299.4°Cat760mmHg
• Flash Point: 125.7°C
• PSA: 35.53000
• Density: 1.262g/cm³
• LogP: 1.27030
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-Methoxybenzofuran-3(2H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-METHOXY-BENZOFURAN-3-ONE

There total 20 articles about 5-METHOXY-BENZOFURAN-3-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-methoxybenzofuran-3-yl acetate (60770-33-4) → 5-methoxy-benzofuran-3-one (39581-55-0)

Guidance literature:

With hydrogenchloride; water; In methanol; for 5h; Reflux;

DOI:10.1016/j.bmcl.2010.08.004

Reference yield: 92.0%

2-chloro-1-(2-hydroxy-5-methoxyphenyl)ethan-1-one (75717-53-2) → 5-methoxy-benzofuran-3-one (39581-55-0)

Guidance literature:

With sodium acetate; In ethanol; for 2h; Reflux;

DOI:10.1016/j.ejmech.2010.09.061

Reference yield: 88.0%

2-ethynyl-4-methoxyphenol (99299-73-7) → 5-methoxy-benzofuran-3-one (39581-55-0)

Guidance literature:

With 2-chloropyridine-N-oxide; mercuric triflate; In dichloromethane; at 23 ℃; for 1h;

DOI:10.1021/acs.orglett.0c01096

upstream raw materials:

2-chloro-1-(2-hydroxy-5-methoxyphenyl)ethan-1-one

2,5-dimethoxybenzoic acid

2,5-dimethoxybenzoyl chloride

4-methoxy-phenol

Downstream raw materials:

methyl 2-(5-methoxybenzofuran-3-yl)acetate

5-methoxy-3-oxo-2-phenylmethylidene-2,3-dihydrobenzo[b]furan

C₁₁H₉NO₂

Refernces

• 1、 Dai, Ning,Hu, Weican,Qian, Guoying,Rong, Zhouting. "A Hg(OTf)2-Catalyzed Enolate Umpolung Reaction Enables the Synthesis of Coumaran-3-ones and Indolin-3-ones". supporting information. p. 3286 - 3290. Retrieved 2020/04/21.
• 2、 Hu, Xiaojing,Lai, Huimin,Zhao, Fangfei,Hu, Shuyu,Sun, Qianqian,Fang, Lizhen. "Microwave-Assisted Synthesis of Benzofuran-3(2H)-ones". . p. 745 - 750. Retrieved 2019/10/14.