N-Ethyl-D-glucamine

Base Information

• Chemical Name: N-Ethyl-D-glucamine
• CAS No.: 14216-22-9
• Molecular Formula: C8H19NO5
• Molecular Weight: 209.243
• Hs Code.: 29221990
• European Community (EC) Number: 238-073-8
• UNII: K94D9J0608
• DSSTox Substance ID: DTXSID30161956
• Nikkaji Number: J216.913D
• Wikidata: Q27282114
• Mol file: 14216-22-9.mol

Synonyms:14216-22-9;N-Ethyl-D-glucamine;N-ethylglucamine;Eglumine;(2R,3R,4R,5S)-6-(Ethylamino)hexane-1,2,3,4,5-pentaol;N-Ethyl glucamine;1-Deoxy-1-(ethylamino)-D-glucitol;D-Glucitol, 1-deoxy-1-(ethylamino)-;(2R,3R,4R,5S)-6-(ethylamino)hexane-1,2,3,4,5-pentol;EINECS 238-073-8;UNII-K94D9J0608;K94D9J0608;(2R,3R,4R,5S)-6-(Ethylamino)-hexane-1,2,3,4,5-pentaol;N-ETHYLGLCAE;ethylglucamine;MFCD03789564;D-N-ETHYLGLUCAMIN;D-(-)-N-Ethylglucamine;SCHEMBL123685;DTXSID30161956;N-Ethyl-D-glucamine, >=98.0%;AC8067;AKOS015915241;AC-17086;DS-16295;AM20080320;CS-0151979;E0923;GLUCITOL, 1-DEOXY-1-(ETHYLAMINO)-, D-;A807860;Q-201461;Q27282114;6-(ethylamino)hexane-1,2,3,4,5-pentol

Chemical Property of N-Ethyl-D-glucamine

Chemical Property:

• Appearance/Colour: White crystalline powder, odourless or almost odourless
• Melting Point: 136-140 °C
• Boiling Point: 489.8 °C at 760 mmHg
• PKA: 13.51±0.20(Predicted)
• Flash Point: 235.6 °C
• PSA: 113.18000
• Density: 1.32 g/cm³
• LogP: -2.57730
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: H2O: 0.1 g/mL, clear, colorless
• XLogP3: -2.5
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 209.12632271
• Heavy Atom Count: 14
• Complexity: 146

Purity/Quality:

99%, ^*data from raw suppliers

N-Ethyl-D-glucamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCNCC(C(C(C(CO)O)O)O)O
• Isomeric SMILES: CCNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O
• Uses: N-Ethyl-D-glucamine is an ethylated amino sugar derived from Glucose (G595000). It has low vapor pressure and good thermal stability in air, and is used in self-driven microfluidic method to pattern organic films directly in air.

Technology Process of N-Ethyl-D-glucamine

There total 4 articles about N-Ethyl-D-glucamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.69%

D-glucose (50-99-7) + ethylamine (75-04-7,85404-22-4) → N-ethyl-D-glucamine (14216-22-9)

Guidance literature:

D-glucose; ethylamine; With hydrogen; In methanol; at 25 - 35 ℃; for 0.5h;

In methanol; at 60 - 80 ℃; for 12h; Reagent/catalyst; Solvent; Sealed tube; Inert atmosphere;

Reference yield:

→ N-ethyl-D-glucamine (14216-22-9)

Guidance literature:

With methanol; palladium on activated charcoal; at 15 - 40 ℃; under 18387.7 Torr; Hydrogenation;

DOI:10.1002/hlca.193501801187

Reference yield:

methanol (67-56-1) + D-glucose-ethylimine → N-ethyl-D-glucamine (14216-22-9)

Guidance literature:

at 15 - 40 ℃; under 18387.7 Torr; Hydrogenation;

DOI:10.1002/hlca.193501801187

upstream raw materials:

D-glucose

ethylamine

methanol

Downstream raw materials:

[4-(6-chloro-7-methylamino-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylurea N-ethylglucamine salt

Refernces

• 1、 -. "USE OF 9-OXOACRIDINE-10-ACETIC ACID, SALTS AND ESTERS THEREOF IN COMBINATION THERAPY OF OVARIAN CANCER". . . Retrieved 2010/04/30.
• 2、 -. "Process for the resolution of d,1 2-(6-methoxy-2-naphthyl)propionic acid". . . Retrieved 2008/06/13.