3-CHLORO-N-(4-CHLORO-PHENYL)-PROPIONAMIDE

Base Information

• Chemical Name: 3-CHLORO-N-(4-CHLORO-PHENYL)-PROPIONAMIDE
• CAS No.: 19314-16-0
• Molecular Formula: C9H9 Cl2 N O
• Molecular Weight: 218.083
• Hs Code.: 2924299090
• Mol file: 19314-16-0.mol

Synonyms:Propionanilide,3,4'-dichloro- (8CI)

Chemical Property of 3-CHLORO-N-(4-CHLORO-PHENYL)-PROPIONAMIDE

Chemical Property:

• Vapor Pressure: 3.17E-06mmHg at 25°C
• Melting Point: 132～134℃
• Boiling Point: 388°Cat760mmHg
• Flash Point: 188.4°C
• PSA: 29.10000
• Density: 1.343g/cm³
• LogP: 2.98040

Purity/Quality:

98%min ^*data from raw suppliers

3-Chloro-N-(4-chlorophenyl)propanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLORO-N-(4-CHLORO-PHENYL)-PROPIONAMIDE

There total 4 articles about 3-CHLORO-N-(4-CHLORO-PHENYL)-PROPIONAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-chloro-aniline (106-47-8) + 2-chloropropionyl chloride (625-36-5) → 3-chloro-N-(4-chlorophenyl)propanamide (19314-16-0)

Guidance literature:

In acetone; for 1h; Heating;

DOI:10.1021/jm000945r

Reference yield:

3-chloropropanoyl bromide + 4-chloro-aniline (106-47-8) → 3-chloro-N-(4-chlorophenyl)propanamide (19314-16-0)

Guidance literature:

With triethylamine; In chloroform;

DOI:10.1007/s12272-012-0805-4

Reference yield:

3-chloropropionylisothiocyanate (19565-19-6) + 4-chloro-aniline (106-47-8) → 3-chloro-N-(4-chlorophenyl)propanamide (19314-16-0)

Guidance literature:

In benzene; Ambient temperature;

upstream raw materials:

4-chloro-aniline

2-chloropropionyl chloride

3-chloropropionylisothiocyanate

Downstream raw materials:

6-chloro-1,2,3,4-tetrahydroquinolin-2-one

C₁₂H₁₂ClN₃OS₂

N-(4'-chlorophenyl)-2-azetidinone

2,6-Dichloro-3-chloromethyl-quinoline

Refernces

• 1、 Shen, Sida,Picci, Cristina,Ustinova, Kseniya,Benoy, Veronick,Kutil, Zsófia,Zhang, Guiping,Tavares, Maurício T.,Pavlí?ek, Ji?í,Zimprich, Chad A.,Robers, Matthew B.,Van Den Bosch, Ludo,Ba?inka, Cyril,Langley, Brett,Kozikowski, Alan P.. "Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model". . p. 4810 - 4840. Retrieved 2021/05/07.
• 2、 Kozikowski, Alan P.,Shen, Sida,Pardo, Marta,Tavares, Maurício T.,Szarics, Dora,Benoy, Veronick,Zimprich, Chad A.,Kutil, Zsófia,Zhang, Guiping,Ba?inka, Cyril,Robers, Matthew B.,Van Den Bosch, Ludo,Eubanks, James H.,Jope, Richard S.. "Brain Penetrable Histone Deacetylase 6 Inhibitor SW-100 Ameliorates Memory and Learning Impairments in a Mouse Model of Fragile X Syndrome". . p. 1679 - 1695. Retrieved 2019/01/04.