tert-butyl (1RS,6SR)-7-ox...

Base Information

• Chemical Name: tert-butyl (1RS,6SR)-7-ox...
• CAS No.: 161157-50-2
• Molecular Formula: C10H17NO3
• Molecular Weight: 199.25
• Hs Code.: 2934999090
• Mol file: 161157-50-2.mol

Synonyms:tert-butyl (1R,6S)-7-oxa-4-azabicyclo[4.1.0]heptane-4-carboxylate;tert-Butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate;

Chemical Property of tert-butyl (1RS,6SR)-7-ox...

Chemical Property:

• Boiling Point: 272.5±23.0 °C(Predicted)
• PKA: -0.83±0.20(Predicted)
• PSA: 42.07000
• Density: 1.141±0.06 g/cm3(Predicted)
• LogP: 1.33250
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

tert-Butyl 7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl (1RS,6SR)-7-ox...

There total 11 articles about tert-butyl (1RS,6SR)-7-ox... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl 1,2,3,4-tetrahydro-1-pyridinecarboxylate (131667-57-7) → tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate (161157-50-2)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 3.25h;

Reference yield: 98.0%

N-Boc-1,2,3,6-tetrahydropyridine (85838-94-4) → tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate (161157-50-2)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1016/j.tetlet.2004.07.111

Reference yield:

3,4-epoxy-piperidine-1-carboxylic acid benzyl ester (66207-08-7,1624258-63-4) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate (161157-50-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃;

upstream raw materials:

N-Boc-1,2,3,6-tetrahydropyridine

1,2,3,6-tetrahydropyridine

ethyl 1,2,3,6-tetrahydropyridine-1-carboxylate

di-tert-butyl dicarbonate

Downstream raw materials:

racemic trans-tert-butyl 4-fluoro-3-hydroxypiperidine-1-carboxylate

tert-butyl 3-oxo-3,6-dihydropyridine-1 (2H)-carboxylate

Refernces

• 1、 -. "INHIBITORS OF LEUCINE RICH REPEAT KINASE 2". Page/Page column 152. . Retrieved 2019/02/02.
• 2、 -. "HETEROCYCLIC COMPOUND". Paragraph 0502. . Retrieved 2018/03/25.