4-CHLORO-2,6-BIS(DIMETHYLAMINO)PYRIMIDINE

Base Information

• Chemical Name: 4-CHLORO-2,6-BIS(DIMETHYLAMINO)PYRIMIDINE
• CAS No.: 1202-22-8
• Molecular Formula: C₈H₁₃ClN₄
• Molecular Weight: 200.671
• Hs Code.: 2933599090
• Mol file: 1202-22-8.mol

Synonyms:2,4-Pyrimidinediamine,6-chloro-N,N,N',N'-tetramethyl- (9CI); Pyrimidine,4-chloro-2,6-bis(dimethylamino)- (6CI,7CI,8CI);2,4-Bis(dimethylamino)-6-chloropyrimidine;4-Chloro-2,6-bis(dimethylamino)pyrimidine;6-Chloro-N,N,N',N'-tetramethylpyrimidine-2,4-diamine

Chemical Property of 4-CHLORO-2,6-BIS(DIMETHYLAMINO)PYRIMIDINE

Chemical Property:

• Vapor Pressure: 0.000132mmHg at 25°C
• Boiling Point: 334°Cat760mmHg
• Flash Point: 155.8°C
• PSA: 32.26000
• Density: 1.224g/cm³
• LogP: 1.26200

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-CHLORO-2,6-BIS(DIMETHYLAMINO)PYRIMIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-CHLORO-2,6-BIS(DIMETHYLAMINO)PYRIMIDINE

There total 5 articles about 4-CHLORO-2,6-BIS(DIMETHYLAMINO)PYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

2,4,6-trichloropyrimidine (3764-01-0) + dimethyl amine (124-40-3) → 6-chloro-N2,N2,N4,N4-tetrapyrimidin-2,4-diamine (1202-22-8)

Guidance literature:

In ethanol; water; at 40 ℃; for 0.833333h;

DOI:10.1021/jm00378a016

Reference yield:

2,4,6-trichloropyrimidine (3764-01-0) + dimethyl amine (124-40-3) → 6-chloro-N2,N2,N4,N4-tetrapyrimidin-2,4-diamine (1202-22-8) + 4,6-dichloro-N,N-dimethyl-pyrimidin-2-amine (5734-68-9) + 2,6-dichloro-N,N-dimethylpyrimidin-4-amine (117077-93-7)

Guidance literature:

In ethanol; acetone; acetonitrile; at -15 ℃; for 2h;

DOI:10.1002/ejoc.200900529

Reference yield:

2,6-dichloro-N,N-dimethylpyrimidin-4-amine (117077-93-7) + dimethyl amine (124-40-3) → 6-chloro-N2,N2,N4,N4-tetrapyrimidin-2,4-diamine (1202-22-8) + 2-chloro-N,N,N',N'-tetramethyl-pyrimidine-4,6-diamine (771556-94-6)

Guidance literature:

2,6-dichloro-N,N-dimethylpyrimidin-4-amine; dimethyl amine; In water; isopropyl alcohol; for 3.5h; Heating / reflux;

With sodium hydrogencarbonate; In water; isopropyl alcohol;

upstream raw materials:

2,4,6-trichloropyrimidine

dimethyl amine

4,6-dichloro-N,N-dimethyl-pyrimidin-2-amine

2,6-dichloro-N,N-dimethylpyrimidin-4-amine

Downstream raw materials:

N²,N²-dimethyl-N⁴,N⁶-di-p-tolyl-pyrimidine-2,4,6-triyltriamine

Refernces

• 1、 Dracinsky, Martin,Holy, Antonin,Jansa, Petr,Kovackova, Sona,Budesinsky, Milos. "Isotopic exchange of hydrogen at C-5 in pyrimidine derivatives: tautomers with an sp3-hybridised C-5 carbon atom". experimental part. p. 4117 - 4122. Retrieved 2009/12/26.
• 2、 -. "Amines useful in producing pharmaceutically active CNS compounds". . . Retrieved 2008/06/13.