Difluoxacin hydrochloride

Base Information

• Chemical Name: Difluoxacin hydrochloride
• CAS No.: 91296-86-5
• Molecular Formula: C21H19F2N3O3^.HCl
• Molecular Weight: 435.858
• Mol file: 91296-86-5.mol

Synonyms:3-Quinolinecarboxylicacid,6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-,monohydrochloride (9CI);

Chemical Property of Difluoxacin hydrochloride

Chemical Property:

• Appearance/Colour: off-white to pale yellow solid
• Vapor Pressure: 5.01E-15mmHg at 25°C
• Melting Point: >245 °C (dec.)
• Refractive Index: 1.629
• Boiling Point: 595.5 °C at 760 mmHg
• Flash Point: 313.9 °C
• PSA: 65.78000
• Density: 1.409 g/cm³
• LogP: 3.52380
• Storage Temp.: 0-6°C
• Solubility.: Soluble in aqueous buffer

Purity/Quality:

99% ^*data from raw suppliers

DifloxacinHydrochlorideSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Difloxacin is a fluoroquinolone antibiotic. It is active against isolates of anaerobic bacteria, including B. fragilis, as well as Fusobacterium and Actinomyces species with MIC values ranging from ≤0.125 to 8 μg/ml. It eliminates E. coli and B. fragilis infection in a rat intra-abdominal abscess model when administered at a dose of 40 mg/kg three times per day.
• Uses: antibacterial, DNA gyrase inhibitor A quinolone antibacterial compound. Structurally related to norfloxacin A fluoroquinolone antibacterial structurally related to norfloxacin.

Technology Process of Difluoxacin hydrochloride

There total 2 articles about Difluoxacin hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.3%

C25H24BF2N3O7 → Difloxacin hydrochloride (91296-86-5)

Guidance literature:

With hydrogenchloride; In water; at 0 ℃; for 4h; pH=< 1;

Reference yield:

1-methyl-piperazine (109-01-3) + C20H13BF3NO7 → Difloxacin hydrochloride (91296-86-5)

Guidance literature:

Multi-step reaction with 2 steps

1: ethyl trimethylsilyl ether / acetonitrile / 20 °C

2: hydrogenchloride / water / 4 h / 0 °C / pH < 1

With hydrogenchloride; ethyl trimethylsilyl ether; In water; acetonitrile;

upstream raw materials:

1-methyl-piperazine

Refernces