2-ANILINO-1,4-NAPHTHOQUINONE

Base Information

• Chemical Name: 2-ANILINO-1,4-NAPHTHOQUINONE
• CAS No.: 6628-97-3
• Molecular Formula: C16H11 N O2
• Molecular Weight: 249.269
• Hs Code.: 2922399090
• Mol file: 6628-97-3.mol

Synonyms:1,4-Naphthoquinone,2-anilino- (6CI,7CI,8CI); 1,4-Dihydro-1,4-dioxo-2-(phenylamino)naphthalene;2-Anilino-1,4-naphthoquinone; 2-Phenylamino-1,4-naphthalenedione;2-Phenylamino-1,4-naphthoquinone; NSC 59789

Chemical Property of 2-ANILINO-1,4-NAPHTHOQUINONE

Chemical Property:

• Vapor Pressure: 2.56E-07mmHg at 25°C
• Melting Point: 193°C
• Refractive Index: 1.5300 (estimate)
• Boiling Point: 421.7°C at 760 mmHg
• Flash Point: 168.8°C
• PSA: 46.17000
• Density: 1.343g/cm³
• LogP: 3.13460

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ANILINO-1,4-NAPHTHOQUINONE

There total 65 articles about 2-ANILINO-1,4-NAPHTHOQUINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

aniline (62-53-3) + [1,4]naphthoquinone (130-15-4) → 2-(phenylamino)naphthoquinone (6628-97-3)

Guidance literature:

With copper(II) acetate monohydrate; acetic acid; at 60 - 70 ℃; for 0.416667h; Under air;

DOI:10.1021/jo200354u

Reference yield: 93.0%

nitrobenzene (98-95-3,26969-40-4) + [1,4]naphthoquinone (130-15-4) → 2-(phenylamino)naphthoquinone (6628-97-3)

Guidance literature:

With zinc(II) acetate dihydrate; acetic acid; zinc; In water; at 20 ℃; for 5h; Reagent/catalyst; Solvent;

DOI:10.1055/s-0037-1610689

Reference yield: 85.0%

2-methoxy-1,4-naphthoquinone (2348-82-5) + aniline (62-53-3) → 2-(phenylamino)naphthoquinone (6628-97-3)

Guidance literature:

With magnesium chloride hexahydrate; toluene-4-sulfonic acid; In methanol; for 6h; Reflux;

DOI:10.1016/j.molstruc.2008.03.028

upstream raw materials:

ethyl bromide

ethanol

4-(phenylamino)naphthalene-1,2-dione

2-hydroxynaphtho-1,4-quinone

Downstream raw materials:

2-hydroxynaphtho-1,4-quinone

2-(4-nitrophenylamino)-1,4-naphthoquinone

2-(4-bromophenylamino)-3-bromonaphthalene-1,4-dione

1,2,3,4,5,10-Hexahydro-3-methyl-5,10-dioxo-1-phenyl-benzo-3-chinazolinium-perchlorat

Refernces

• 1、 Cardoso, Silvia Helena,de Oliveira, Cleidijane Rodrigues,Guimar?es, Ari Souza,Nascimento, Jadiely,de Oliveira dos Santos Carmo, Julianderson,de Souza Ferro, Jamylle Nunes,de Carvalho Correia, Ana Carolina,Barreto, Emiliano. "". . p. 55 - 64. Retrieved 2018.
• 2、 Cardoso, Sílvia Helena,Guimar?es, Ari Souza,McKerrow, James H.,Silva, Leandro Rocha,da Silva, Elany Barbosa,da Silva-Júnior, Edeildo Ferreira,do Nascimento, Jadiely,do Santos Nascimento, Igor José. "Computer-aided design of 1,4-naphthoquinone-based inhibitors targeting cruzain and rhodesain cysteine proteases". . . Retrieved 2021/05/21.