4-(aminomethyl)-N,N-dimethylbenzamide(SALTDATA: 1.27HCl 0.45H2O)

Base Information

• Chemical Name: 4-(aminomethyl)-N,N-dimethylbenzamide(SALTDATA: 1.27HCl 0.45H2O)
• CAS No.: 164648-76-4
• Molecular Formula: C10H14N2O
• Molecular Weight: 0.00000
• Hs Code.: 2924297099
• Mol file: 164648-76-4.mol

Synonyms:

Chemical Property of 4-(aminomethyl)-N,N-dimethylbenzamide(SALTDATA: 1.27HCl 0.45H2O)

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

98% ^*data from raw suppliers

4-(aminomethyl)-N,N-dimethylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(aminomethyl)-N,N-dimethylbenzamide(SALTDATA: 1.27HCl 0.45H2O)

There total 2 articles about 4-(aminomethyl)-N,N-dimethylbenzamide(SALTDATA: 1.27HCl 0.45H2O) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

4-(acetamidomethyl)-N,N-dimethylbenzamide → 4-(aminomethyl)-N,N-dimethylbenzamide (164648-76-4)

Guidance literature:

With hydroxylamine trifluoroacetate; In tetrahydrofuran; at 80 ℃; for 5h; chemoselective reaction;

DOI:10.1002/ejoc.201800304

Reference yield:

N,N-dimethyl-4-[(trifluoroacetamido)methyl]benzamide (1240044-01-2) → 4-(aminomethyl)-N,N-dimethylbenzamide (164648-76-4)

Guidance literature:

With ammonium hydroxide; In methanol; water; at 60 ℃; for 8h; Sealed tube;

DOI:10.1021/jm100432w

Reference yield: 86.0%

4-(aminomethyl)-N,N-dimethylbenzamide (164648-76-4) + acetic anhydride (108-24-7) → 4-(acetamidomethyl)-N,N-dimethylbenzamide

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1002/ejoc.201800304

upstream raw materials:

N,N-dimethyl-4-[(trifluoroacetamido)methyl]benzamide

Downstream raw materials:

C₁₆H₁₈N₂O₃

Refernces

• 1、 Robins, Morris J.,Peng, Yunshan,Damaraju, Vijaya L.,Mowles, Delores,Barron, Geraldine,Tackaberry, Tracey,Young, James D.,Cass, Carol E.. "Improved syntheses of 5′- S -(2-Aminoethyl)-6- N -(4-nitrobenzyl)- 5′-thioadenosine (SAENTA), analogues, and fluorescent probe conjugates: Analysis of cell-surface human equilibrative nucleoside transporter 1 (hENT1) levels for prediction of the antitumor". experimental part. p. 6040 - 6053. Retrieved 2010/11/02.