4-Chlorophenyl 2-methylprop-2-enoate

Base Information

• Chemical Name: 4-Chlorophenyl 2-methylprop-2-enoate
• CAS No.: 16522-37-5
• Molecular Formula: C10H9ClO2
• Molecular Weight: 196.633
• ChEMBL ID: CHEMBL3274791
• DSSTox Substance ID: DTXSID70496476
• Nikkaji Number: J799.881C
• Wikidata: Q82345360
• Mol file: 16522-37-5.mol

Synonyms:16522-37-5;p-chlorophenyl methacrylate;4-chlorophenyl methacrylate;SCHEMBL452065;CHEMBL3274791;DTXSID70496476;SIADNYSYTSORRE-UHFFFAOYSA-N;4-Chlorophenyl 2-methylprop-2-enoate

Chemical Property of 4-Chlorophenyl 2-methylprop-2-enoate

Chemical Property:

• PSA: 26.30000
• LogP: 2.82150
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 196.0291072
• Heavy Atom Count: 13
• Complexity: 205

Purity/Quality:

2-Methyl-2-propenoicacid,4-chlorophenylester 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=C)C(=O)OC1=CC=C(C=C1)Cl

Technology Process of 4-Chlorophenyl 2-methylprop-2-enoate

There total 2 articles about 4-Chlorophenyl 2-methylprop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-chloro-phenol (106-48-9,82344-39-6) + Methacryloyl chloride (920-46-7,26937-45-1) → p-chlorophenyl β-chloroisobutyrate (1189544-22-6) + 4-chlorophenyl methacrylate (16522-37-5)

Guidance literature:

With sodium hydroxide; In water; at 10 ℃; for 0.5h;

DOI:10.1134/S1070427209010236

Reference yield:

4-chloro-phenol (106-48-9,82344-39-6) + Methacryloyl chloride (920-46-7,26937-45-1) → 4-chlorophenyl methacrylate (16522-37-5)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01525a052 DOI:10.1021/ja01123a523

upstream raw materials:

4-chloro-phenol

Methacryloyl chloride

Refernces

• 1、 Kobyakova,Kuz'Mina,Beshenova,Beloded. "Development of the conditions of synthesis of p-chlorophenyl methacrylate of the desired purity grade". experimental part. p. 123 - 127. Retrieved 2009/09/06.