2-Fluoro-3-sodiooxyacrylic acid ethyl ester

Base Information

• Chemical Name: 2-Fluoro-3-sodiooxyacrylic acid ethyl ester
• CAS No.: 1652-39-7
• Molecular Formula: C5H7FO3.Na
• Molecular Weight: 156.089
• Mol file: 1652-39-7.mol

Synonyms:

Chemical Property of 2-Fluoro-3-sodiooxyacrylic acid ethyl ester

Chemical Property:

• PSA: 49.36000
• LogP: 0.79090

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Fluoro-3-sodiooxyacrylic acid ethyl ester

There total 1 articles about 2-Fluoro-3-sodiooxyacrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 2-fluoroacetate (459-72-3) + formic acid ethyl ester (109-94-4) → sodium 3-ethoxy-2-fluoro-3-oxoprop-1-en-1-olate (1652-39-7)

Guidance literature:

With sodium hydride; In diethyl ether; ethanol; mineral oil; at 20 ℃; Inert atmosphere; Cooling with ice;

Reference yield: 93.0%

5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamidine + sodium 3-ethoxy-2-fluoro-3-oxoprop-1-en-1-olate (1652-39-7) → 5-fluoro-2-(5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-ol

Guidance literature:

With ethanol; for 3h; Reflux;

Reference yield: 65.0%

malonodiamide (108-13-4) + sodium 3-ethoxy-2-fluoro-3-oxoprop-1-en-1-olate (1652-39-7) → 5-fluoro-2,6-dihydroxynicotinamide (75993-41-8)

Guidance literature:

With sodium ethanolate; In ethanol; for 0.333333h; Heating;

DOI:10.1248/cpb.35.2280

upstream raw materials:

ethyl 2-fluoroacetate

formic acid ethyl ester

Downstream raw materials:

5-fluoro-2,6-dihydroxynicotinamide

5-fluoro-2,6-dihydroxynicotinonitrile

5-fluoro-2-(1-(2-fluorobenzyl)-5-(isoxazol-3-yl)-1H-pyrazol-3-yl)pyrimidin-4(3H)-one

C₁₈H₁₃F₂N₅O₂

Refernces

• 1、 -. "INHIBITION OF OLIG2 ACTIVITY". Paragraph 00501-00502. . Retrieved 2018/03/25.
• 2、 Miyamoto,Egawa,Matsumoto. "Pyridonecarboxylic acids as antibacterial agents. VIII. An alternative synthesis of enoxacin via fluoronicotinic acid derivatives". . p. 2280 - 2285. Retrieved 2007/10/02.