METHYL BIPHENYL-2-CARBOXYLATE

Base Information

• Chemical Name: METHYL BIPHENYL-2-CARBOXYLATE
• CAS No.: 16605-99-5
• Molecular Formula: C14H12O2
• Molecular Weight: 212.248
• Hs Code.: 2916399090
• Mol file: 16605-99-5.mol

Synonyms:2-biphenylcarboxylic acid methyl ester;Biphenyl-2-carbonsaeuremethylester;methyl phenylbenzoate;methyl [1,1'-biphenyl]-2-carboxylate;2-methoxycarbonyl-1,1'-biphenyl;RARECHEM AL BF 0859;1,1'-biphenyl-2-carboxylic acid methylester;methyl 2-phenylbenzoate;

Chemical Property of METHYL BIPHENYL-2-CARBOXYLATE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 114-115 °C
• Boiling Point: 347.388oC at 760 mmHg
• Flash Point: 163.357oC
• PSA: 26.30000
• Density: 1.102g/cm3
• LogP: 3.14020

Purity/Quality:

97% ^*data from raw suppliers

Methylbiphenyl-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL BIPHENYL-2-CARBOXYLATE

There total 74 articles about METHYL BIPHENYL-2-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

o-iodo-methyl-benzoic acid (610-97-9) + phenylboronic acid (98-80-6) → biphenyl-2-carboxylic acid methyl ester (16605-99-5)

Guidance literature:

With sodium methylate; In 1,4-dioxane; at 100 ℃; for 25h; Schlenk technique;

DOI:10.1021/cs400468h

Reference yield: 96.7%

methanol (67-56-1) + 2-Biphenylcarboxylic acid (947-84-2) → biphenyl-2-carboxylic acid methyl ester (16605-99-5)

Guidance literature:

With sulfuric acid; for 6h; Reflux;

Reference yield: 96.0%

2-bromobenzoic acid methyl ester (610-94-6) + phenylboronic acid (98-80-6) → biphenyl-2-carboxylic acid methyl ester (16605-99-5)

Guidance literature:

With potassium phosphate; dichloro{bis[1-(dicyclohexylphosphanyl)piperidine]}palladium(II); In toluene; at 80 ℃; for 0.166667h; Air;

DOI:10.1002/chem.200903309

upstream raw materials:

2-Methoxycarbonyl-benzenediazonium

benzene

bis-(2-methoxycarbonyl-benzoyl)-peroxide

methanol

Refernces

• 1、 Kutonova, Ksenia V.,Jung, Nicole,Trusova, Marina E.,Filimonov, Victor D.,Postnikov, Pavel S.,Br?se, Stefan. "Arenediazonium Tosylates (ADTs) as Efficient Reagents for Suzuki-Miyaura Cross-Coupling in Neat Water". . p. 1680 - 1688. Retrieved 2017.
• 2、 Lei, Xiangyang,Obregon, Karla A.,Alla, Jhansi. "Suzuki-Miyaura coupling reactions of aryl chlorides catalyzed by a new nickel(II) σ-aryl complex". . p. 419 - 424. Retrieved 2013.
• 3、 Yang, Qing,Ma, Shengming,Li, Jixue,Xiao, Fengshou,Xiong, Hai. "A water-compatible, highly active and reusable PEG-coated mesoporous silica-supported palladium complex and its application in Suzuki coupling reactions". . p. 2495 - 2497. Retrieved 2006.
• 4、 Ermolaev,Arkhipova,Nigmatullina,Rizvanov,Milyukov,Sinyashin. "Palladium nanoparticles stabilized by sterically hindered phosphonium salts as Suzuki cross-coupling catalysts". . p. 657 - 660. Retrieved 2013.
• 5、 Loupy, André,Maurel, Fran?ois,Sabatié-Gogová, Andrea. "Improvements in Diels-Alder cycloadditions with some acetylenic compounds under solvent-free microwave-assisted conditions: Experimental results and theoretical approaches". . p. 1683 - 1691. Retrieved 2004.
• 6、 Sengupta, Saumitra,Bhattacharyya, Sanchita. "Palladium-Catalyzed Cross-Coupling of Arenediazonium Salts with Arylboronic Acids". . p. 3405 - 3406. Retrieved 1997.
• 7、 Guo, Zhifo,Lei, Xiangyang. "New Nickel-Based Catalytic System with Pincer Pyrrole-Functionalized N-Heterocyclic Carbene as Ligand for Suzuki-Miyaura Cross-Coupling Reactions". . . Retrieved 2021.
• 8、 Dwadnia, Nejib,Roger, Julien,Pirio, Nadine,Cattey, Hélène,Ben Salem, Ridha,Hierso, Jean-Cyrille. "Gold-Catalyzed Suzuki Coupling of ortho-Substituted Hindered Aryl Substrates". . p. 459 - 464. Retrieved 2017.
• 9、 Wang, Congcong,Zhang, Yu-Fang,Guo, Shimeng,Zhao, Quan,Zeng, Yanping,Xie, Zhicheng,Xie, Xin,Lu, Boxun,Hu, Youhong. "GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes". . p. 941 - 957. Retrieved 2020/11/30.
• 10、 Bettoni, Léo,Joly, Nicolas,Lohier, Jean-Fran?ois,Gaillard, Sylvain,Poater, Albert,Renaud, Jean-Luc. "Ruthenium-Catalyzed Three-Component Alkylation: A Tandem Approach to the Synthesis of Nonsymmetric N,N-Dialkyl Acyl Hydrazides with Alcohols". supporting information. p. 4009 - 4017. Retrieved 2021/07/02.