tert-butyl-2-furoate

Base Information

• Chemical Name: tert-butyl-2-furoate
• CAS No.: 16737-36-3
• Molecular Formula: C9H12O3
• Molecular Weight: 168.192
• Mol file: 16737-36-3.mol

Synonyms:furan-2-carboxylic acid tert-butyl ester;Furan-2-carbonsaeure-tert-butylester;

Chemical Property of tert-butyl-2-furoate

Chemical Property:

• PSA: 39.44000
• LogP: 2.23490

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of tert-butyl-2-furoate

There total 10 articles about tert-butyl-2-furoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-furanoic acid (88-14-2) + 2-tert-butoxypyridine (83766-88-5) → tert-butyl furan-2-carboxylate (16737-36-3)

Guidance literature:

With boron trifluoride diethyl etherate; In toluene; at 20 ℃; for 0.5h;

DOI:10.1016/j.tet.2018.05.050

Reference yield: 83.0%

furfural (98-01-1) + di-tert-butyl peroxide (110-05-4) → tert-butyl furan-2-carboxylate (16737-36-3)

Guidance literature:

With copper(I) bromide; In hexane; at 50 ℃; for 5h; Inert atmosphere;

DOI:10.1039/c3ra40246k

Reference yield: 74.0%

2-furoic acid methyl ester (611-13-2) + potassium tert-butylate (865-47-4) → tert-butyl furan-2-carboxylate (16737-36-3)

Guidance literature:

In diethyl ether; at 20 ℃;

DOI:10.1055/s-2001-13356

upstream raw materials:

2-furancarbonyl chloride

tert-butyl alcohol

sodium t-butanolate

2-furanoic acid

Downstream raw materials:

2-furanoic acid

isobutene

Refernces

• 1、 Holdren,Barry. "-". . p. 1230. Retrieved 1947.
• 2、 Jiang, Huanfeng,Jiang, Kai,Li, Yingwei,Luo, Wenkun,Yin, Biaolin. "Direct Alkoxycarbonylation of Heteroarenes via Cu-Mediated Trichloromethylation and in Situ Alcoholysis". supporting information. . Retrieved 2020/03/04.
• 3、 La, Minh Thanh,Kim, Hee-Kwon. "A fast and practical synthesis of tert-butyl esters from 2-tert-butoxypyridine using boron trifluoride·diethyl etherate under mild conditions". . p. 3748 - 3754. Retrieved 2018/05/28.