1,4-DIOXA-8-AZA-SPIRO[4.6]UNDECANE

Base Information

• Chemical Name: 1,4-DIOXA-8-AZA-SPIRO[4.6]UNDECANE
• CAS No.: 16803-07-9
• Molecular Formula: C8H15NO2
• Molecular Weight: 157.213
• Mol file: 16803-07-9.mol

Synonyms:Hexahydro-4H-azepin-4-on-ethylenketal;1,4-dioxa-8-aza-spiro[4.6]undecane;1,4-Dioxa-8-aza-spiro<4.6>undecan;8-Aza-1,4-dioxaspiro<4.6>undecan;

Chemical Property of 1,4-DIOXA-8-AZA-SPIRO[4.6]UNDECANE

Chemical Property:

• Boiling Point: 247.8±35.0 °C(Predicted)
• PKA: 11.24±0.20(Predicted)
• PSA: 30.49000
• Density: 1.08±0.1 g/cm3(Predicted)
• LogP: 0.83180

Purity/Quality:

98% ^*data from raw suppliers

1,4-Dioxa-8-aza-spiro[4.6]undecane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-DIOXA-8-AZA-SPIRO[4.6]UNDECANE

There total 6 articles about 1,4-DIOXA-8-AZA-SPIRO[4.6]UNDECANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-Aza-1,5-cycloheptanedione (37637-20-0) + ethylene glycol (107-21-1) → 1,4-dioxan-8-azaspiro[4.6]undecane (16803-07-9)

Guidance literature:

2-Aza-1,5-cycloheptanedione; ethylene glycol; With toluene-4-sulfonic acid; In toluene; at 120 ℃; for 2h;

With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at 20 ℃; for 5h; Temperature;

Reference yield:

ethyl 1,4-dioxa-8-azaspiro[4.6]undecane-8-carboxylate (346735-03-3) → 1,4-dioxan-8-azaspiro[4.6]undecane (16803-07-9)

Guidance literature:

With potassium hydroxide; In water; isopropyl alcohol;

Reference yield:

8-benzyl-1,4-dioxa-8-aza-spiro[4.6]undecane (16803-06-8) → 1,4-dioxan-8-azaspiro[4.6]undecane (16803-07-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/jo01272a035

upstream raw materials:

8-benzyl-1,4-dioxa-8-aza-spiro[4.6]undecane

1-benzoylazepan-4-one

ethyl 1,4-dioxa-8-azaspiro[4.6]undecane-8-carboxylate

2-Aza-1,5-cycloheptanedione

Downstream raw materials:

1-methyl-1,2,3,5,6,7-hexahydroazepin-4-one hydrochloride

8-[2-(4-methoxyphenyl)ethyl]-1,4-dioxa-8-azaspiro[4.6]undecane

Refernces

• 1、 -. "Method for preparing N-methyl azepine-4-one hydrochloride". . . Retrieved 2021/06/09.