(4-PHENOXYPHENYL)METHYLAMINE HYDROCHLORIDE

Base Information

• Chemical Name: (4-PHENOXYPHENYL)METHYLAMINE HYDROCHLORIDE
• CAS No.: 169944-04-1
• Molecular Formula: C13H13NO.ClH
• Molecular Weight: 235.70900
• Hs Code.: 2922299090
• Mol file: 169944-04-1.mol

Synonyms:(4-Phenoxyphenyl)methylamine hydrochloride;

Chemical Property of (4-PHENOXYPHENYL)METHYLAMINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 2.84E-05mmHg at 25°C
• Boiling Point: 351.7oC at 760 mmHg
• Flash Point: 166.5oC
• PSA: 35.25000
• LogP: 4.43990
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

(4-Phenoxyphenyl)methanaminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4-PHENOXYPHENYL)METHYLAMINE HYDROCHLORIDE

There total 5 articles about (4-PHENOXYPHENYL)METHYLAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-phenoxy benzaldehyde (67-36-7) → (4-phenoxyphenyl)methanamine monohydrochloride (169944-04-1)

Guidance literature:

4-phenoxy benzaldehyde; With hydroxylamine hydrochloride; In ethanol; water; at 20 ℃;

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In ethanol; water; for 6h; under 760.051 Torr;

Reference yield:

4-phenoxybenzonitrile (3096-81-9) → (4-phenoxyphenyl)methanamine monohydrochloride (169944-04-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tris(pentafluorophenyl)borate / chloroform-d1 / 2 h / 25 °C / Inert atmosphere

2: hydrogenchloride; water / diethyl ether / 1 h / 20 °C

With hydrogenchloride; tris(pentafluorophenyl)borate; water; In diethyl ether; chloroform-d1;

DOI:10.1021/acs.joc.5b00941

Reference yield:

C21H33NOSi2 → (4-phenoxyphenyl)methanamine monohydrochloride (169944-04-1)

Guidance literature:

With hydrogenchloride; water; In diethyl ether; at 20 ℃; for 1h;

DOI:10.1021/acs.joc.5b00941

upstream raw materials:

4-phenoxy benzaldehyde

4-phenoxybenzonitrile

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS". Paragraph 0313-0314. . Retrieved 2020/07/16.
• 2、 Labes, Ricardo,González-Calderón, Davir,Battilocchio, Claudio,Mateos, Carlos,Cumming, Graham R.,De Frutos, Oscar,Rincón, Juan A.,Ley, Steven V.. "Rapid Continuous Ruthenium-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines". supporting information. p. 2855 - 2858. Retrieved 2017/10/06.