4-ACETOXY-3,5-DIMETHOXYBENZOIC ACID

Base Information

• Chemical Name: 4-ACETOXY-3,5-DIMETHOXYBENZOIC ACID
• CAS No.: 6318-20-3
• Molecular Formula: C11H12 O6
• Molecular Weight: 240.213
• Hs Code.: 2918990090
• Mol file: 6318-20-3.mol

Synonyms:Benzoicacid, 4-hydroxy-3,5-dimethoxy-, acetate (7CI); Syringic acid, acetate (6CI);4-Acetoxy-3,5-dimethoxybenzoic acid; NSC 15296

Chemical Property of 4-ACETOXY-3,5-DIMETHOXYBENZOIC ACID

Chemical Property:

• Vapor Pressure: 3.7E-05mmHg at 25°C
• Melting Point: 190-191°C
• Boiling Point: 338.9°C at 760 mmHg
• Flash Point: 127.4°C
• PSA: 82.06000
• Density: 1.28g/cm³
• LogP: 1.32730

Purity/Quality:

98%,99%, ^*data from raw suppliers

AcetylsyringicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-ACETOXY-3,5-DIMETHOXYBENZOIC ACID

There total 13 articles about 4-ACETOXY-3,5-DIMETHOXYBENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,5-dimethoxy-4-hydroxybenzoic acid (530-57-4) + acetic anhydride (108-24-7) → O-acetylsyringic acid (6318-20-3)

Guidance literature:

With dmap; In dichloromethane; for 3h;

Reference yield: 66.4%

3,5-dimethoxy-4-hydroxybenzoic acid (530-57-4) + acetyl chloride (75-36-5) → O-acetylsyringic acid (6318-20-3)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2011.05.073

Reference yield:

3,5-dimethoxy-4-hydroxybenzoic acid (530-57-4) → O-acetylsyringic acid (6318-20-3)

Guidance literature:

With pyridine; acetic anhydride;

upstream raw materials:

pyridine

malvidin chloride

acetyl chloride

3-(4-acetoxy-3,5-dimethoxyphenyl)prop-2-enoic acid

Downstream raw materials:

3,5-dimethoxy-4-hydroxybenzoic acid

O-acetylsyringic acid chloride

4-acetoxy-3,5-dimethoxy-2-nitrobenzoic acid

(R)-4-(2,3-bis(tert-butoxycarbonyl)guanidino)butyl 4-((2-((tert-butoxycarbonyl)amino)-3-(prop-2-yn-1-ylthio)propanoyl)oxy)-3,5-dimethoxybenzoate

Refernces

• 1、 -. "Leonurine derivative and application thereof in preparing medicine for preventing or treating ischemic cerebrovascular diseases". Paragraph 0035-0037. . Retrieved 2021/03/30.
• 2、 Liu, Junkai,Luo, Shanshan,Ma, Fenfen,Xu, Shengtao,Zhu, Yi Zhun. "Design and synthesis of novel SCM-198 analogs as cardioprotective agents: Structure-activity relationship studies and biological evaluations". . . Retrieved 2020/06/03.