5,15-Dihete

Base Information Edit

Chemical Name:5,15-Dihete
CAS No.:82200-87-1
Molecular Formula:C₂₀H₃₂O₄
Molecular Weight:336.472
Hs Code.:
DSSTox Substance ID:DTXSID401157454
Wikidata:Q27163191
Metabolomics Workbench ID:2636
Mol file:82200-87-1.mol

Synonyms:5(S),15(S)-dihydroxy-6,13-trans-8,11-cis-eicosatetraenoic acid;5,15-diHETE;5,15-dihydroxy-6,8,11,13-eicosatetraenoic acid

Suppliers and Price of 5,15-Dihete

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5(S),15(S)-DiHETE
100μg
$ 210.00

Cayman Chemical
5(S),15(S)-DiHETE ≥98%
100μg
$ 284.00

Cayman Chemical
5(S),15(S)-DiHETE ≥98%
50μg
$ 150.00

Cayman Chemical
5(S),15(S)-DiHETE ≥98%
25μg
$ 79.00

American Custom Chemicals Corporation
5S,15S-DIHYDROXY-6E,8Z,10Z,13E-EICOSATETRAENOIC ACID 95.00%
5MG
$ 498.86

AHH
5(S),15(S)-Dihete 98%
0.00025g
$ 328.00

Total 6 raw suppliers

Chemical Property of 5,15-Dihete Edit

Chemical Property:

Appearance/Colour:Colorless oil
Vapor Pressure:8.43E-14mmHg at 25°C
Refractive Index:1.527
Boiling Point:537.6 °C at 760 mmHg
Flash Point:293 °C
PSA：77.76000
Density:1.04 g/cm³
LogP:4.15830
Storage Temp.:-20°C
XLogP3:4
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:14
Exact Mass:336.23005950
Heavy Atom Count:24
Complexity:421

Purity/Quality:

99% ^*data from raw suppliers

5(S),15(S)-DiHETE ^*data from reagent suppliers

Safty Information:

Pictogram(s): F,Xi
Hazard Codes:F,Xi
Statements: 11-36/37/38
Safety Statements: 16-26-36

MSDS Files:

Useful:

Canonical SMILES:CCCCCC(C=CC=CCC=CC=CC(CCCC(=O)O)O)O
Isomeric SMILES:CCCCC[C@@H](/C=C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)O)O
Description 5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE. It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB4. 5(S),15(S)-DiHETE is chemotactic for eosinophils with an ED50 value of 0.3 μM.
Uses 5(S),15(S)-DiHETE is synthesized by 15-LO from 5(S)-HETE. It potentiates the degranulation of human PMNL in response to PAF, but not fMLP, calcium ionophore A23187, or LTB4. 5(S),15(S)-DiHETE is chemotactic for eosinophils with an ED50 value of 0.3 μM. 5(S),15(S)-DiHETE is an enhancer of neutrophil degranulation and potent chemotaxin.

Technology Process of 5,15-Dihete

There total 3 articles about 5,15-Dihete which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 506-32-1,236743-58-1
all cis 5,8,11,14-eicosatetraenoic acid

: 82200-87-1
5(S),15(S)-dihydroxy-6E,8Z,11Z,13E-eicosatetraenoic acid

: 80234-65-7
8(S),15(S) dihydroxy 5Z,9E,11Z,13E eicosatetraenoic acid

Guidance literature:: With sodium tetrahydroborate; soybean lipoxygenase; oxygen; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) 23 deg C, 24 h, borate buffer, pH 11;
DOI:10.1016/S0040-4039(01)80684-5

Reference yield:

: 61641-47-2,70608-72-9,71030-39-2,71774-09-9,72255-35-7,73307-52-5,74080-72-1,88588-79-8
5(S)-HETE

: 82200-87-1
5(S),15(S)-dihydroxy-6E,8Z,11Z,13E-eicosatetraenoic acid

Guidance literature:: 5(S)-HETE; With dipotassium hydrogenphosphate; soybean seed lipoxygenase-1; for 0.0166667h; pH=10; aq. buffer; Enzymatic reaction;

pH=4; aq. buffer;

With triphenylphosphine; In methanol; at 20 ℃; for 0.25h;
DOI:10.1194/jlr.M001719