1-(4-Chlorobenzyl)piperidin-4-amine 2,2,2-trifluoroacetate

Base Information

• Chemical Name: 1-(4-Chlorobenzyl)piperidin-4-amine 2,2,2-trifluoroacetate
• CAS No.: 78471-44-0
• Molecular Formula: C12H17ClN2
• Molecular Weight: 224.733
• DSSTox Substance ID: DTXSID30585830
• Mol file: 78471-44-0.mol

Synonyms:1-(4-chlorobenzyl)piperidin-4-amine trifluoroacetate;1078161-60-0;1-(4-Chlorobenzyl)piperidin-4-amine 2,2,2-trifluoroacetate;1-[(4-chlorophenyl)methyl]piperidin-4-amine, trifluoroacetic acid;SCHEMBL1920595;DTXSID30585830;OALRRWRZHRJPER-UHFFFAOYSA-N;AKOS008054056;CS-0285554;EN300-14491;Z104341880;1-(4-Chlorobenzyl)piperidin-4-amine2,2,2-trifluoroacetate;1-(4-CHLOROBENZYL)-4-PIPERIDINAMINE TRIFLUOROACETATE;1-[(4-chlorophenyl)methyl]piperidin-4-amine;trifluoroacetic acid;Trifluoroacetic acid--1-[(4-chlorophenyl)methyl]piperidin-4-amine (1/1)

Chemical Property of 1-(4-Chlorobenzyl)piperidin-4-amine 2,2,2-trifluoroacetate

Chemical Property:

• Vapor Pressure: 0.000559mmHg at 25°C
• Refractive Index: 1.571
• Boiling Point: 311.6 °C at 760 mmHg
• Flash Point: 142.2 °C
• PSA: 66.56000
• Density: 1.15 g/cm³
• LogP: 3.53460
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 2
• Exact Mass: 338.1008900
• Heavy Atom Count: 22
• Complexity: 266

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Chlorobenzyl)piperidin-4-amine2,2,2-trifluoroacetate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1N)CC2=CC=C(C=C2)Cl.C(=O)(C(F)(F)F)O

Technology Process of 1-(4-Chlorobenzyl)piperidin-4-amine 2,2,2-trifluoroacetate

There total 12 articles about 1-(4-Chlorobenzyl)piperidin-4-amine 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

1-(p-chlorobenzyl)-4-piperidone oxime (68726-76-1) → 1-(4-chloro-benzyl)-piperidin-4-ylamine (78471-44-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; for 19h; Heating;

Reference yield: 59.0%

4-amino-1-(4-chloro-benzyl)-pyridinium chloride (1052528-90-1,1132650-62-4) → 1-(4-chloro-benzyl)-piperidin-4-ylamine (78471-44-0)

Guidance literature:

4-amino-1-(4-chloro-benzyl)-pyridinium chloride; With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 15 - 26 ℃;

With sodium hydroxide; In tetrahydrofuran; methanol; water; Product distribution / selectivity;

Reference yield:

tert-butyl 1-(4-chlorobenzyl)piperidin-4-ylcarbamate (1286275-72-6) → 1-(4-chloro-benzyl)-piperidin-4-ylamine (78471-44-0)

Guidance literature:

tert-butyl 1-(4-chlorobenzyl)piperidin-4-ylcarbamate; With trifluoroacetic acid; In dichloromethane;

With sodium hydroxide; In dichloromethane;

DOI:10.1016/j.ejmech.2011.04.016

upstream raw materials:

1-(p-chlorobenzyl)-4-piperidone oxime

4-carboxamide-1-(4-chlorobenzyl)piperidine

1-Chloro-4-(chloromethyl)benzene

4-amino-1-(4-chloro-benzyl)-pyridinium chloride

Downstream raw materials:

2-[((2S)-3-{[1-(4-chlorobenzyl)piperidin-4-yl]amino}-2-hydroxypropyl)oxy]benzonitrile

N-{2-[((2S)-3-{[1-(4-chlorobenzyl)piperidin-4-yl]amino}-2-hydroxy-2-methylpropyl)oxy]-4-hydroxyphenyl}acetamide

4-{5-bromo-2-[1-(4-chloro-benzyl)-piperidin-4-ylamino]-pyrimidin-4-yloxy}-3,5-dimethyl-benzonitrile

N-(1-(4-chlorobenzyl)piperidin-4-yl)-6-chloro-2-methoxyacridin-9-amine

Refernces

• 1、 Huang, Wanrong,Zhang, Yue,Liang, Xu,Yang, Lichun. "Substituted 2-thioxothiazolidin-4-one derivatives showed protective effects against diabetic cataract via inhibition of aldose reductase". . . Retrieved 2020/04/07.
• 2、 Zhao, Fu-Chun,Wu, Yan,Song, Xiao-Jie. "Design and development of a novel chalcone derivative as an anticholinesterase inhibitor for possible treatment of dementia". . p. 3311 - 3317. Retrieved 2017/07/17.