Ethyl (2-methoxyphenoxy)acetate

Base Information

• Chemical Name: Ethyl (2-methoxyphenoxy)acetate
• CAS No.: 13078-21-2
• Molecular Formula: C11H14O4
• Molecular Weight: 210.23
• Hs Code.: 2918990090
• European Community (EC) Number: 235-977-4
• UNII: FJ76E63KZH
• DSSTox Substance ID: DTXSID40156737
• Nikkaji Number: J266.761D
• Wikidata: Q72475741
• Mol file: 13078-21-2.mol

Synonyms:ethyl 2-(2-methoxyphenoxy)acetate;13078-21-2;ETHYL 2-METHOXYPHENOXYACETATE;Ethyl (2-methoxyphenoxy)acetate;Acetic acid, (2-methoxyphenoxy)-, ethyl ester;FJ76E63KZH;EINECS 235-977-4;AI3-10576;UNII-FJ76E63KZH;ethyl-2-methoxyphenoxyacetate;SCHEMBL5318188;DTXSID40156737;AMY18100;CS-D0564;MFCD00082657;STK399864;AKOS000308020;(2-Methoxyphenoxy)acetic Acid Ethyl Este;(o-Methoxyphenoxy)acetic acid ethyl ester;DS-15465;(2-Methoxyphenoxy)acetic Acid Ethyl Ester;2-(o-Methoxyphenoxy)acetic acid ethyl ester;E1241;FT-0608885;FT-0625752;A806144;Acetic acid, 2-(2-methoxyphenoxy)-, ethyl ester

Chemical Property of Ethyl (2-methoxyphenoxy)acetate

Chemical Property:

• Vapor Pressure: 0.00419mmHg at 25°C
• Refractive Index: 1.492
• Boiling Point: 278.7 °C at 760 mmHg
• Flash Point: 118 °C
• PSA: 44.76000
• Density: 1.103 g/cm³
• LogP: 1.63710
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 210.08920892
• Heavy Atom Count: 15
• Complexity: 193

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl2-(2-Methoxyphenoxy)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)COC1=CC=CC=C1OC

Technology Process of Ethyl (2-methoxyphenoxy)acetate

There total 17 articles about Ethyl (2-methoxyphenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl bromoacetate (105-36-2) + 2-methoxy-phenol (90-05-1) → ethyl 2-(2-methoxyphenoxy)acetate (13078-21-2)

Guidance literature:

With potassium carbonate; In acetone; Reflux;

DOI:10.1021/acs.orglett.6b02651

Reference yield: 92.0%

ethanol (64-17-5) + (2-methoxyphenoxy)acetic acid (1878-85-9) → ethyl 2-(2-methoxyphenoxy)acetate (13078-21-2)

Guidance literature:

With toluene-4-sulfonic acid; at 20 ℃;

DOI:10.1007/s00044-009-9170-3

Reference yield: 85.4%

→ ethyl 2-(2-methoxyphenoxy)acetate (13078-21-2)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; acetone; for 12h; Reflux;

upstream raw materials:

chloroacetic acid ethyl ester

2-methoxy-phenol

ethanol

(2-methoxyphenoxy)acetic acid

Downstream raw materials:

(2-Methoxy-phenoxy)-acethydroxamsaeure

(2-methoxyphenoxy)acetic acid

erythro-1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol

threo-1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol

Refernces

• 1、 Al-Ostoot, Fares Hezam,Sherapura, Ankith,V, Vigneshwaran,Basappa, Giridhara,H.K, Vivek,B.T, Prabhakar,Khanum, Shaukath Ara. "Targeting HIF-1α by newly synthesized Indolephenoxyacetamide (IPA) analogs to induce anti-angiogenesis-mediated solid tumor suppression". . p. 1328 - 1343. Retrieved 2021/05/03.
• 2、 Bal, Mathias,Bomon, Jeroen,Liao, Yuhe,Maes, Bert U. W.,Sels, Bert F.,Sergeyev, Sergey,Van Den Broeck, Elias,Van Speybroeck, Veronique. "Br?nsted Acid Catalyzed Tandem Defunctionalization of Biorenewable Ferulic acid and Derivates into Bio-Catechol". supporting information. p. 3063 - 3068. Retrieved 2020/02/05.