4-acetyloxybenzyl bis(3'-azido-3'-deoxythymidin-5-yl) phosphate

Base Information

• Chemical Name: 4-acetyloxybenzyl bis(3'-azido-3'-deoxythymidin-5-yl) phosphate
• CAS No.: 171284-23-4
• Molecular Formula: C₂₉H₃₃N₁₀O₁₂P
• Molecular Weight: 744.615
• Mol file: 171284-23-4.mol

Synonyms:

Chemical Property of 4-acetyloxybenzyl bis(3'-azido-3'-deoxythymidin-5-yl) phosphate

Chemical Property:

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Technology Process of 4-acetyloxybenzyl bis(3'-azido-3'-deoxythymidin-5-yl) phosphate

There total 1 articles about 4-acetyloxybenzyl bis(3'-azido-3'-deoxythymidin-5-yl) phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3'-azido-2',3'-deoxythymidine (30516-87-1,399024-19-2) + 4-acetoxybenzyl N,N,N’,N’-tetraisopropylphosphoramidite (171284-20-1) → 4-acetyloxybenzyl bis(3'-azido-3'-deoxythymidin-5-yl) phosphate (171284-23-4)

Guidance literature:

With 1H-tetrazole; 3-chloro-benzenecarboperoxoic acid; Yield given. Multistep reaction; 1.) MeCN, 30 min, 2.) - 40 deg C - room temperature; room temperature, 5 min;

DOI:10.1080/15257779508009491

upstream raw materials:

3'-azido-2',3'-deoxythymidine

4-acetoxybenzyl N,N,N’,N’-tetraisopropylphosphoramidite

Refernces