6-Chlorocinnoline

Base Information

• Chemical Name: 6-Chlorocinnoline
• CAS No.: 17404-91-0
• Molecular Formula: C8H5ClN2
• Molecular Weight: 164.59200
• Hs Code.: 2933990090
• Mol file: 17404-91-0.mol

Synonyms:6-Chlor-cinnoline;6-chloro-cinnoline;6-Chlor-cinnolin;

Chemical Property of 6-Chlorocinnoline

Chemical Property:

• Melting Point: 129-130℃
• PSA: 25.78000
• Density: 1.349
• LogP: 2.28320
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

6-Chlorocinnoline 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Chlorocinnoline

There total 15 articles about 6-Chlorocinnoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-(4-chloro-2-ethynylphenyl)-3,3-diethyltriazene → 6-chlorocinnoline (17404-91-0)

Guidance literature:

In 1,2-dichloro-benzene; at 200 ℃;

DOI:10.1021/ol006517x

Reference yield: 96.0%

(4-chloro-2-ethynyl-phenyl)-piperidin-1-yl-diazene (477909-74-3) → 6-chlorocinnoline (17404-91-0)

Guidance literature:

In 1,2-dichloro-benzene; at 200 ℃; for 16h;

DOI:10.1021/ja027809r

Reference yield: 70.0%

diethyl 6-chlorodihydrocinnoline-1,2-dicarboxylate (1393462-56-0) → 6-chlorocinnoline (17404-91-0)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 70 ℃; for 16h;

DOI:10.1002/anie.201201529

upstream raw materials:

4,6-dichlorocinnoline

toluene-4-sulfonic acid hydrazide

6-chloro-4-hydrazino-cinnoline

C₁₉H₂₂ClN₅O₂S

Refernces

• 1、 Kimball, David B.,Herges, Rainer,Haley, Michael M.. "Two unusual, competitive mechanisms for (2-ethynylphenyl)triazene cyclization: Pseudocoarctate versus pericyclic reactivity". . p. 1572 - 1573. Retrieved 2002.
• 2、 Kimball, David B.,Weakley, Timothy J. R.,Haley, Michael M.. "Cyclization of 1-(2-alkynylphenyl)-3,3-dialkyltriazenes: A convenient, high-yield synthesis of substituted cinnolines and isoindazoles". . p. 6395 - 6405. Retrieved 2007/10/03.