4-Nitrovaleric acid methyl ester

Base Information

• Chemical Name: 4-Nitrovaleric acid methyl ester
• CAS No.: 10312-37-5
• Molecular Formula: C6H11 N O4
• Molecular Weight: 161.158
• Hs Code.: 2915900090
• Mol file: 10312-37-5.mol

Synonyms:Valericacid, 4-nitro-, methyl ester (7CI,8CI); 4-Nitropentanoic acid methyl ester;Methyl 4-nitropentanoate; NSC 23473

Chemical Property of 4-Nitrovaleric acid methyl ester

Chemical Property:

• Vapor Pressure: 0.0535mmHg at 25°C
• Boiling Point: 234.2°C at 760 mmHg
• Flash Point: 103.8°C
• PSA: 72.12000
• Density: 1.117g/cm³
• LogP: 1.12800

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Nitrovaleric acid methyl ester

There total 9 articles about 4-Nitrovaleric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

Nitroethane (79-24-3) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → methyl 4-nitropentanoate (10312-37-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; at 70 - 75 ℃; for 0.0833333h; Microwave irradiation;

DOI:10.3390/molecules14041595

Reference yield: 65.0%

Nitroethane (79-24-3) + acrylic acid (79-10-7) → methyl 4-nitropentanoate (10312-37-5)

Guidance literature:

With sodium hydroxide; In dichloromethane; water; at 20 ℃; for 24h;

DOI:10.1002/adsc.201901000

Reference yield:

Nitroethane (79-24-3) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → levulinic acid methyl ester (624-45-3) + methyl 4-nitropentanoate (10312-37-5)

Guidance literature:

Nitroethane; acrylic acid methyl ester; With copper(l) cyanide; caesium carbonate; In dichloromethane; at 30 - 32 ℃; for 0.5h;

With water; In dichloromethane;

DOI:10.1016/j.tetlet.2012.04.071

upstream raw materials:

methanol

4-bromo-4-nitro-valeric acid methyl ester

potassium acetate

Nitroethane

Downstream raw materials:

(S)-4-tert-Butoxycarbonylamino-pentanoic acid methyl ester

Boc-(R)-γ⁴-Ala-OH

(±)-4-amino-1-pentanol

primaquine

Refernces

• 1、 Ranu, Brindaban C.,Bhar, Sanjay. "Surface-Mediated Phase Reaction: Dramatic Improvement of Michael Reaction on the Surface of Alumina". . p. 1327 - 1332. Retrieved 1992.
• 2、 Ranu, Brindaban C.,Banerjee, Subhash,Jana, Ranjan. "Ionic liquid as catalyst and solvent: the remarkable effect of a basic ionic liquid, [bmIm]OH on Michael addition and alkylation of active methylene compounds". . p. 776 - 782. Retrieved 2007.
• 3、 Kambe,Yasuda. "". . p. 2549. Retrieved 1966.
• 4、 -. "APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS AND USES THEREOF". Paragraph 00369. . Retrieved 2019/04/09.
• 5、 Bosica, Giovanna,Polidano, Kurt. "Solvent-Free Henry and Michael Reactions with Nitroalkanes Promoted by Potassium Carbonate as a Versatile Heterogeneous Catalyst". . . Retrieved 2017/07/11.