4-(benzyloxy)-3-fluorobenzaldehyde

Base Information

• Chemical Name: 4-(benzyloxy)-3-fluorobenzaldehyde
• CAS No.: 175968-61-3
• Molecular Formula: C14H11FO2
• Molecular Weight: 230.239
• Hs Code.: 2913000090
• Mol file: 175968-61-3.mol

Synonyms:3-fluoro-4-phenylmethoxybenzaldehyde;

Chemical Property of 4-(benzyloxy)-3-fluorobenzaldehyde

Chemical Property:

• Melting Point: 94-95 °C(Solv: dichloromethane (75-09-2); hexane (110-54-3))
• Boiling Point: 371.5±27.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.211±0.06 g/cm3(Predicted)
• LogP: 3.21720
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-(Benzyloxy)-3-fluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(benzyloxy)-3-fluorobenzaldehyde

There total 8 articles about 4-(benzyloxy)-3-fluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-fluoro-4-hydroxybenzaldehyde (405-05-0) + benzyl bromide (100-39-0) → 3-fluoro-4-[(phenylmethyl)oxy]benzaldehyde (175968-61-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 55 ℃; for 2h;

DOI:10.1021/jm900409x

Reference yield: 95.0%

4-(benzyloxy)-3-fluorobenzonitrile (1044067-62-0) → 3-fluoro-4-[(phenylmethyl)oxy]benzaldehyde (175968-61-3)

Guidance literature:

4-(benzyloxy)-3-fluorobenzonitrile; With diisobutylaluminium hydride; In hexane; toluene; at 0 ℃; Inert atmosphere;

With hydrogenchloride; water; In hexane; chloroform; toluene; at 20 ℃; for 1h;

Reference yield: 86.0%

3-fluoro-4-hydroxybenzaldehyde (405-05-0) + benzyl chloride (100-44-7) → 3-fluoro-4-[(phenylmethyl)oxy]benzaldehyde (175968-61-3)

Guidance literature:

3-fluoro-4-hydroxybenzaldehyde; With sodium hydride; In N,N-dimethyl-formamide; for 1h; Cooling with ice;

benzyl chloride; In N,N-dimethyl-formamide; for 24h; Reflux;

DOI:10.1016/j.ejmech.2013.11.001

upstream raw materials:

3-fluoro-4-hydroxybenzaldehyde

benzyl bromide

benzyl chloride

4-(benzyloxy)-3-fluorobenzonitrile

Downstream raw materials:

[4-(benzyloxy)-3-fluorophenyl]methanol

6-benzyloxy-5-fluoro-1H-indole-2-carboxylic acid methyl ester

3-(4-benzyloxy-3-fluoro-phenyl)-3-hydroxy-2-isopropoxy-propionic acid ethyl ester

1-(4-(benzyloxy)-3-fluorobenzyl)azetidine-3-carboxylic acid

Refernces

• 1、 -. "PIM KINASE INHIBITOR COMPOSITIONS AND USES THEREOF". Paragraph 0229. . Retrieved 2020/11/12.
• 2、 -. "EP300/CREBBP INHIBITOR". Paragraph 0449; 0450. . Retrieved 2020/05/30.