3'-CHLORO-2-PHENYLACETOPHENONE

Base Information

• Chemical Name: 3'-CHLORO-2-PHENYLACETOPHENONE
• CAS No.: 62482-45-5
• Molecular Formula: C14H11 Cl O
• Molecular Weight: 230.694
• Hs Code.: 2914700090
• Mol file: 62482-45-5.mol

Synonyms:Acetophenone,3'-chloro-2-phenyl- (6CI); Acetophenone, m-chloro-a-phenyl- (3CI); 1-(3-Chlorophenyl)-2-phenylethanone;NSC 59911

Chemical Property of 3'-CHLORO-2-PHENYLACETOPHENONE

Chemical Property:

• Vapor Pressure: 1.76E-05mmHg at 25°C
• Boiling Point: 363.8°C at 760 mmHg
• Flash Point: 197.1°C
• PSA: 17.07000
• Density: 1.191g/cm³
• LogP: 3.76540

Purity/Quality:

99% ^*data from raw suppliers

3'-CHLORO-2-PHENYLACETOPHENONE ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3'-CHLORO-2-PHENYLACETOPHENONE

There total 26 articles about 3'-CHLORO-2-PHENYLACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzyl(bromo)zinc (62673-31-8) + 3-Chlor-thiobenzoesaeure-S-phenylester (97839-36-6) → 1-(m-chlorophenyl)-2-phenylethanone (62482-45-5)

Guidance literature:

With (phenyl)(bis-triphenylphosphine)palladium(II) chloride; In tetrahydrofuran; toluene; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b00031

Reference yield: 93.0%

N-[1-(3-Chloro-phenyl)-1-cyano-2-phenyl-ethyl]-N-phenyl-benzamide (72867-64-2) → 1-(m-chlorophenyl)-2-phenylethanone (62482-45-5)

Guidance literature:

With potassium hydroxide; In ethanol; water; Heating;

DOI:10.1021/jo01295a027

Reference yield: 90.0%

3-chlorophenylboronic acid (63503-60-6) + phenylacetonitrile (140-29-4) → 1-(m-chlorophenyl)-2-phenylethanone (62482-45-5)

Guidance literature:

With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; water; zinc(II) chloride; In 1,4-dioxane; at 80 ℃; for 8h; Inert atmosphere;

DOI:10.1021/ol1003252

upstream raw materials:

3-chlorobenzamide

benzylmagnesium chloride

3-chloro-benzonitrile

N-[1-(3-Chloro-phenyl)-1-cyano-2-phenyl-ethyl]-N-phenyl-benzamide

Downstream raw materials:

4-[3-(3-chlorophenyl)-5-methylisoxazol-4-yl]benzenesulfonamide

6-(3-chlorophenyl)-4-(3-ethoxy-4-hydroxy-5-nitrophenyl)-5-phenyl-3,4-dihydropyrimidin-2(1H)-one

(Z)-1-t-butyldimethylsilyloxy-1-(3-chlorophenyl)-2-phenylethene

1-(3-chlorophenyl)-2-phenylethane-1,2-dione

Refernces

• 1、 Schierle, Simone,Chaikuad, Apirat,Lillich, Felix F.,Ni, Xiaomin,Woltersdorf, Stefano,Schallmayer, Espen,Renelt, Beatrice,Ronchetti, Riccardo,Knapp, Stefan,Proschak, Ewgenij,Merk, Daniel. "Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics". supporting information. p. 5123 - 5136. Retrieved 2021/05/04.
• 2、 Dong, Shunxi,Feng, Xiaoming,He, Jun,Liu, Wen,Liu, Xiaohua,Pu, Maoping,Wu, Yun-Dong,Zhang, Tinghui. "Iron-Catalyzed Enantioselective Radical Carboazidation and Diazidation of α,β-Unsaturated Carbonyl Compounds". supporting information. p. 11856 - 11863. Retrieved 2021/08/16.