5-Ketoenanthic acid methyl ester

Base Information

• Chemical Name: 5-Ketoenanthic acid methyl ester
• CAS No.: 17745-32-3
• Molecular Formula: C8H14O3
• Molecular Weight: 158.197
• Mol file: 17745-32-3.mol

Synonyms:5-oxo-heptanoic acid methyl ester;methyl 5-oxoheptanoate;5-Oxo-heptansaeure-methylester;

Chemical Property of 5-Ketoenanthic acid methyl ester

Chemical Property:

• Boiling Point: 108 °C(Press: 10 Torr)
• PSA: 43.37000
• Density: 0.981±0.06 g/cm3(Predicted)
• LogP: 1.30880

Purity/Quality:

98% ^*data from raw suppliers

methyl5-oxoheptanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Ketoenanthic acid methyl ester

There total 19 articles about 5-Ketoenanthic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 4-(chlorocarbonyl)butyrate (1501-26-4) + ethylmagnesium bromide (925-90-6) → methyl 5-oxoheptanoate (17745-32-3)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1021/jo9719214

Reference yield: 88.0%

methanol (67-56-1) + 2-ethylcyclopentanone (64847-88-7) → methyl 5-oxoheptanoate (17745-32-3)

Guidance literature:

With cerium(IV) sulphate; oxygen; at 50 ℃; for 2h;

DOI:10.1246/bcsj.72.2515

Reference yield: 78.0%

methanol (67-56-1) + 2-methylcyclohexane-1,3-dione (1193-55-1) → methyl 5-oxoheptanoate (17745-32-3)

Guidance literature:

With tropylium tetrafluoroborate; In neat (no solvent); at 100 ℃; for 16h; Inert atmosphere;

DOI:10.1039/C8CC07329E

upstream raw materials:

methyl 4-(chlorocarbonyl)butyrate

5-oxo-hept-6-enoic acid methyl ester

ethylzinc iodide

methanol

Downstream raw materials:

5-[(E)-(S)-1-Phenyl-ethylimino]-hexanoic acid methyl ester

(2R,3S,8aR)-8a-Ethyl-3-methyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

(2R,3S,8aR)-8a-Ethyl-3-methyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridine-5-thione

(2R,3S,7S,8aR)-8a-Ethyl-3,7-dimethyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

Refernces

• 1、 Taylor. "-". . p. 3922. Retrieved 1958.
• 2、 Hussein,Huynh,Hommelsheim,Koenigs,Nguyen. "An efficient method for retro-Claisen-type C-C bond cleavage of diketones with tropylium catalyst". supporting information. p. 12970 - 12973. Retrieved 2018/11/23.
• 3、 Matsuura, Yoshitomo,Chai, Wen,Endoh, Etsuko,Suhara, Jyumpei,Hamada, Hiroki,Horiuchi, C. Akira. "Oxidative cleavage of the C-C bond of 3,6-dialkylcyclohexane-1,2-diones by cell suspension cultures of Marchantia polymorpha". . p. 669 - 673. Retrieved 2007/10/03.