3-Chloro-6-propoxypyridazine

Base Information

• Chemical Name: 3-Chloro-6-propoxypyridazine
• CAS No.: 5788-60-3
• Molecular Formula: C7H9ClN2O
• Molecular Weight: 172.61
• NSC Number: 75065
• DSSTox Substance ID: DTXSID80291358
• Wikidata: Q82029299
• Mol file: 5788-60-3.mol

Synonyms:3-chloro-6-propoxypyridazine;5788-60-3;3-CHLORO-6-PROPYLOXYPYRIDAZINE;NSC75065;SCHEMBL6939611;DTXSID80291358;HXOUDDFFQRLOMP-UHFFFAOYSA-N;3-(n-propoxy)-6-chloropyridazine;MFCD08460980;NSC-75065;AKOS009396953;DS-13051;CS-0163239;FT-0739624;D84183;A915285

Chemical Property of 3-Chloro-6-propoxypyridazine

Chemical Property:

• Vapor Pressure: 0.00163mmHg at 25°C
• Refractive Index: 1.509
• Boiling Point: 303.9 °C at 760 mmHg
• Flash Point: 137.6 °C
• PSA: 35.01000
• Density: 1.191 g/cm³
• LogP: 1.91880
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 172.0403406
• Heavy Atom Count: 11
• Complexity: 113

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-6-propoxypyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCOC1=NN=C(C=C1)Cl

Technology Process of 3-Chloro-6-propoxypyridazine

There total 3 articles about 3-Chloro-6-propoxypyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,6-dichlorpyridazine (141-30-0) + sodium n-propoxide (6819-41-6) → 3-chloro-6-(propyloxy)pyridazine (5788-60-3)

Guidance literature:

In propan-1-ol; at 20 ℃;

DOI:10.1021/jm040063i

Reference yield:

propan-1-ol (71-23-8) + 3,6-dichlorpyridazine (141-30-0) → 3-chloro-6-(propyloxy)pyridazine (5788-60-3)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃;

DOI:10.1002/bkcs.10967

Reference yield:

→ 3-chloro-6-(propyloxy)pyridazine (5788-60-3)

Guidance literature:

/BRN= 122565/;

upstream raw materials:

3,6-dichlorpyridazine

sodium n-propoxide

propan-1-ol

Downstream raw materials:

3-(propyloxy)pyridazine

Refernces

• 1、 Tavares, Francis X.,Boucheron, Joyce A.,Dickerson, Scott H.,Griffin, Robert J.,Preugschat, Frank,Thomso, Stephen A.,Wang, Tony Y.,Zhouf, Hui-Qiang. "N-phenyl-4-pyrazolo[1,5-6]pyridazin-3-ylpyrimidin-2-amines as potent and selective inhibitors of glycogen synthase kinase 3 with good cellular efficacy". . p. 4716 - 4730. Retrieved 2007/10/03.