3,6-Dibromo-1,8-naphthyridine

Base Information

• Chemical Name: 3,6-Dibromo-1,8-naphthyridine
• CAS No.: 17965-79-6
• Molecular Formula: C8H4Br2N2
• Molecular Weight: 287.941
• Nikkaji Number: J82.695B
• Mol file: 17965-79-6.mol

Synonyms:3,6-dibromo-1,8-naphthyridine;17965-79-6;SCHEMBL1500697;1,8-Naphthyridine, 3,6-dibromo-;AKOS024259451

Chemical Property of 3,6-Dibromo-1,8-naphthyridine

Chemical Property:

• PSA: 25.78000
• LogP: 3.15480
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 287.87207
• Heavy Atom Count: 12
• Complexity: 149

Purity/Quality:

99%, ^*data from raw suppliers

3,6-Dibromo-1,8-naphthyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C2C=C(C=NC2=NC=C1Br)Br

Technology Process of 3,6-Dibromo-1,8-naphthyridine

There total 1 articles about 3,6-Dibromo-1,8-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

→ 3,6-dibromo-[1,8]naphthyridine (17965-79-6)

Guidance literature:

Reference yield:

5-methyl-1-phenyl-1H-1,2,3-triazole (6111-96-2) + 3,6-dibromo-[1,8]naphthyridine (17965-79-6) → (6-bromo-[1,8]naphthyridine-3-yl)-1-phenyl-5-methyl-1H-[1,2,3]triazole

Guidance literature:

With sodium acetate; trans-di-μ-acetatebis[2-(di-o-tolylphosphino)benzyl]dipalladium (II); In N,N-dimethyl-formamide; at 140 ℃; for 23h;

Reference yield:

5-methyl-1-phenyl-1H-1,2,3-triazole (6111-96-2) + 3,6-dibromo-[1,8]naphthyridine (17965-79-6) → ([1,8]naphthyridine-3-yl)-1-phenyl-5-methyl-1H-[1,2,3]triazole

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / trans-di-μ-acetatebis[2-(di-o-tolylphosphino)benzyl]dipalladium (II) / N,N-dimethyl-formamide / 23 h / 140 °C

2: potassium hydroxide; hydrogen / palladium hydroxide on carbon / 0.5 h

With potassium hydroxide; hydrogen; sodium acetate; trans-di-μ-acetatebis[2-(di-o-tolylphosphino)benzyl]dipalladium (II); palladium hydroxide on carbon; In N,N-dimethyl-formamide; 1: Heck Reaction;

Refernces