6-AMINO-3,3-DIMETHYL-2,3-DIHYDRO-INDOLE

Base Information

• Chemical Name: 6-AMINO-3,3-DIMETHYL-2,3-DIHYDRO-INDOLE
• CAS No.: 179898-73-8
• Molecular Formula: C10H14N2
• Molecular Weight: 162.23156
• Hs Code.: 2933990090
• Mol file: 179898-73-8.mol

Synonyms:ZINC31777118;

Chemical Property of 6-AMINO-3,3-DIMETHYL-2,3-DIHYDRO-INDOLE

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.567
• Boiling Point: 295.831 °C at 760 mmHg
• PKA: 5.80±0.40(Predicted)
• Flash Point: 154.421 °C
• PSA: 38.05000
• Density: 1.045 g/cm³
• LogP: 2.69110
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

NLT 98% ^*data from raw suppliers

3,3-Dimethylindolin-6-amine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-AMINO-3,3-DIMETHYL-2,3-DIHYDRO-INDOLE

There total 4 articles about 6-AMINO-3,3-DIMETHYL-2,3-DIHYDRO-INDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,3-dimethyl-6-nitro-2,3-dihydro-1H-indole (179898-72-7) → 6-amino-3,3-dimethylindoline (179898-73-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; ethyl acetate; for 5h; under 760 Torr; Yield given;

DOI:10.1016/S0960-894X(98)00107-3

Reference yield:

3,3-dimethylindoline (1914-02-9) → 6-amino-3,3-dimethylindoline (179898-73-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 70percent aq. HNO₃, H₂SO₄ / 0.08 h / 0 °C

2: H₂ / 10percent Pd/C / ethyl acetate; ethanol / 5 h / 760 Torr

With sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal; In ethanol; ethyl acetate;

DOI:10.1016/S0960-894X(98)00107-3

Reference yield:

2-bromoaniline (615-36-1) → 6-amino-3,3-dimethylindoline (179898-73-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / K₂CO₃ / dimethylformamide / Ambient temperature

2: 65 percent / Pd(OAc)2, NaHCO₃ / dimethylformamide / 90 °C

3: 70percent aq. HNO₃, H₂SO₄ / 0.08 h / 0 °C

4: H₂ / 10percent Pd/C / ethyl acetate; ethanol / 5 h / 760 Torr

With palladium diacetate; sulfuric acid; hydrogen; nitric acid; sodium hydrogencarbonate; potassium carbonate; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(98)00107-3

upstream raw materials:

3,3-dimethyl-6-nitro-2,3-dihydro-1H-indole

3,3-dimethylindoline

2-bromoaniline

(2-Bromo-phenyl)-(2-methyl-allyl)-amine

Refernces

• 1、 -. "STEROID RECEPTOR MODULATOR COMPOUNDS AND METHODS". . . Retrieved 2008/06/13.
• 2、 -. "STEROID RECEPTOR MODULATOR COMPOUNDS AND METHODS". . . Retrieved 2008/06/13.