Benzaldehyde, 2-nitro-4,5-bis(phenylmethoxy)-

Base Information

• Chemical Name: Benzaldehyde, 2-nitro-4,5-bis(phenylmethoxy)-
• CAS No.: 18002-41-0
• Molecular Formula: C21H17NO5
• Molecular Weight: 363.37
• Mol file: 18002-41-0.mol

Synonyms:Benzaldehyde,4,5-dibenzyloxy-2-nitro;3,4-Dibenzyloxy-6-nitro-benzaldehyd;

Chemical Property of Benzaldehyde, 2-nitro-4,5-bis(phenylmethoxy)-

Chemical Property:

• Melting Point: 137.5-138.5 °C
• Boiling Point: 574.3±50.0 °C(Predicted)
• PSA: 81.35000
• Density: 1.286±0.06 g/cm3(Predicted)
• LogP: 5.08850

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzaldehyde, 2-nitro-4,5-bis(phenylmethoxy)-

There total 3 articles about Benzaldehyde, 2-nitro-4,5-bis(phenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(Chloromethoxy)-4-hydroxy-2-nitrobenzaldehyde (73635-74-2) → 4,5-bis(benzyloxy)-2-nitrobenzaldehyde (18002-41-0)

Guidance literature:

Multi-step reaction with 2 steps

1: KI / tetrahydrofuran; aq. HCl / 6 h / Heating

2: 1) K₂CO₃ / EtOH 2) aq.HCl / 1) ca.5-6h /reflux 2) 30 min / r.t.

With hydrogenchloride; ethanol; potassium carbonate; potassium iodide; In tetrahydrofuran; hydrogenchloride;

DOI:10.1021/jo01302a003

Reference yield:

4,5-dihydroxy-2-nitrobenzaldehyde (73635-75-3) + benzyl bromide (100-39-0) → 4,5-bis(benzyloxy)-2-nitrobenzaldehyde (18002-41-0)

Guidance literature:

With hydrogenchloride; ethanol; potassium carbonate; Yield given; 1) ca.5-6h /reflux 2) 30 min / r.t.;

DOI:10.1021/jo01302a003

Reference yield:

→ 4,5-bis(benzyloxy)-2-nitrobenzaldehyde (18002-41-0)

Guidance literature:

Aus dem entspr. 3,4-Dihydroxy-benzaldehyd u. PhCH2Cl ;

upstream raw materials:

4,5-dihydroxy-2-nitrobenzaldehyde

benzyl bromide

5-(Chloromethoxy)-4-hydroxy-2-nitrobenzaldehyde

Downstream raw materials:

2-(4,5-Bis-benzyloxy-2-nitro-benzylidene)-malonic acid

6,7-bis-benzyloxy-coumarin

bis(benzyloxy)-6-nitroisoproterenol

{(S)-1-[4,5-Bis-benzyloxy-2-(2,2-dibromo-vinyl)-phenylcarbamoyl]-ethyl}-carbamic acid benzyl ester

Refernces