[Zn(II)(4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide)(DL-phenylalaninate)(H₂O)2](acetate)*H₂O

Base Information

• Chemical Name: [Zn(II)(4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide)(DL-phenylalaninate)(H₂O)2](acetate)*H₂O
• CAS No.: 797790-89-7
• Molecular Formula: C₂H₃O₂*C₂₄H₂₇N₄O₈SZn*H₂O
• Molecular Weight: 674.016
• Mol file: 797790-89-7.mol

Synonyms:

Chemical Property of [Zn(II)(4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide)(DL-phenylalaninate)(H₂O)2](acetate)*H₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [Zn(II)(4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide)(DL-phenylalaninate)(H₂O)2](acetate)*H₂O

There total 2 articles about [Zn(II)(4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide)(DL-phenylalaninate)(H₂O)2](acetate)*H₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Phenylalanine (150-30-1,25191-15-5,658-69-5,67675-33-6) + zinc diacetate (557-34-6) + Piroxicam (36322-90-4) → [Zn(II)(4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide)(DL-phenylalaninate)(H2O)2](acetate)*H2O (797790-89-7)

Guidance literature:

In ethanol; water; hot soln. (60°C) of metal salt in H2O was added to mixt. of hot ethanol soln. (60°C) of piroxicam and soln. of DL-phenylalanine inEtOH in molar ratio 1:1:1; mixt. stirred under reflux for 30 min; ppt. filtered; washed (hot EtOH, Et2O); dried (vac., CaCl2); elem. anal.;

DOI:10.1016/j.saa.2005.06.042

Reference yield:

Phenylalanine (150-30-1,25191-15-5,658-69-5,67675-33-6) + water (7732-18-5) + zinc(II) acetate dihydrate (5970-45-6) + Piroxicam (36322-90-4) → [Zn(II)(4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide)(DL-phenylalaninate)(H2O)2](acetate)*H2O (797790-89-7)

Guidance literature:

In ethanol; water; soln. of Zn salt in deionized water added to hot EtOH soln. (60°C) of piroxicam (molar ratio 1:1); phenylalanine (1 equiv.) in EtOH added; stirred under reflux for 30 min; filtered; ppt. washed with hot EtOH and Et2O; dried in vac. desiccator over anhyd. CaCl2; elem. anal.;

DOI:10.1016/j.saa.2004.01.035

Reference yield:

[Zn(II)(4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide)(DL-phenylalaninate)(H2O)2](acetate)*H2O (797790-89-7) → [Zn(4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide)(DL-phenylalanine)(H2O)2](acetate) (797790-88-6)

Guidance literature:

In neat (no solvent); byproducts: H2O; heated in dynamic N2 atm. (20 ml/min) with a heating rate of 10°C/min to 200°C; Kinetics;

DOI:10.1016/j.saa.2005.06.042

upstream raw materials:

Phenylalanine

water

zinc(II) acetate dihydrate

Piroxicam

Downstream raw materials:

[Zn(4-hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide)(DL-phenylalanine)(H₂O)2](acetate)

Refernces

• 1、 Zayed,El-Dien, F.A. Nour,Mohamed, Gehad G.,El-Gamel, Nadia E.A.. "Synthesis and thermal characterization of new ternary chelates of piroxicam and tenoxicam with glycine and dl-phenylalanine and some transition metals". . p. 216 - 232. Retrieved 2007/10/03.