Acetamide, N,N'-[(4-fluorophenyl)methylene]bis-

Base Information

• Chemical Name: Acetamide, N,N'-[(4-fluorophenyl)methylene]bis-
• CAS No.: 181260-33-3
• Molecular Formula: C11H13FN2O2
• Molecular Weight: 224.235
• Mol file: 181260-33-3.mol

Synonyms:

Chemical Property of Acetamide, N,N'-[(4-fluorophenyl)methylene]bis-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetamide, N,N'-[(4-fluorophenyl)methylene]bis-

There total 2 articles about Acetamide, N,N'-[(4-fluorophenyl)methylene]bis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

acetamide (60-35-5) + 4-fluorobenzaldehyde (459-57-4) → N-[(acetylamino)(4-fluorophenyl)methyl]acetamide (181260-33-3)

Guidance literature:

With silica-bonded S-sullfonic acid nanoparticles; In toluene; for 3h; Reflux;

DOI:10.1080/00397911.2012.709573

Reference yield:

4-fluorobenzylic alcohol (459-56-3) → N-[(acetylamino)(4-fluorophenyl)methyl]acetamide (181260-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 2-hydroxy-N,N,N-trimethyl ethanaminium peroxydisulfate / neat (no solvent) / 0.5 h / 70 °C / Green chemistry

2: choline hydrogen sulphate / neat (no solvent) / 0.15 h / 70 °C / Green chemistry

With choline hydrogen sulphate; 2-hydroxy-N,N,N-trimethyl ethanaminium peroxydisulfate; In neat (no solvent);

DOI:10.1039/c4nj02295e

Reference yield:

N-[(acetylamino)(4-fluorophenyl)methyl]acetamide (181260-33-3) → α-amino-(4'-fluorophenyl-)methanephosphonic acid (125553-06-2)

Guidance literature:

N-[(acetylamino)(4-fluorophenyl)methyl]acetamide; With phosphorus trichloride; In acetic acid; for 3h; Heating;

With hydrogenchloride; for 10h; Heating;

DOI:10.1016/S0031-9422(01)00425-3

upstream raw materials:

acetamide

4-fluorobenzaldehyde

4-fluorobenzylic alcohol

Downstream raw materials:

α-amino-(4'-fluorophenyl-)methanephosphonic acid

Refernces

• 1、 Gadilohar, Balu L.,Kumbhar, Haribhau S.,Shankarling, Ganapati S.. "Choline peroxydisulfate oxidizing Bio-TSIL: Triple role player in the one-pot synthesis of Betti bases and gem-bisamides from aryl alcohols under solvent-free conditions". . p. 4647 - 4657. Retrieved 2015/06/16.
• 2、 Karimi-Jaberi, Zahed,Pooladian, Baharak. "A mild, efficient, and environmentally friendly synthesis of N,N′-arylidene bisamides using B(HSO4)3 under solvent-free conditions". . p. 659 - 663. Retrieved 2013/07/26.