DIISOPROPYLAMINOACETONITRILE

Base Information

• Chemical Name: DIISOPROPYLAMINOACETONITRILE
• CAS No.: 54714-49-7
• Molecular Formula: C8H16N2
• Molecular Weight: 140.228
• Hs Code.: 2926909090
• Mol file: 54714-49-7.mol

Synonyms:Acetonitrile,[bis(1-methylethyl)amino]- (9CI);Diisopropylaminoacetonitrile;NSC 26718;

Chemical Property of DIISOPROPYLAMINOACETONITRILE

Chemical Property:

• Vapor Pressure: 0.26mmHg at 25°C
• Refractive Index: 1.439
• Boiling Point: 204.7 °C at 760 mmHg
• PKA: 6.39±0.28(Predicted)
• Flash Point: 67.4 °C
• PSA: 27.03000
• Density: 0.865 g/cm³
• LogP: 1.62878

Purity/Quality:

99% ^*data from raw suppliers

(Diisopropylamino)acetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of DIISOPROPYLAMINOACETONITRILE

There total 7 articles about DIISOPROPYLAMINOACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.4%

chloroacetonitrile (107-14-2) + diisopropylamine (108-18-9) → N-cyanomethyl-N,N-diisopropylamine (54714-49-7)

Guidance literature:

With potassium carbonate; In toluene; at 100 ℃; for 5h; Solvent; Temperature; Reagent/catalyst;

Reference yield:

N,N-diisopropylmethylamine (10342-97-9) + trimethylsilyl cyanide (7677-24-9) → N-cyanomethyl-N,N-diisopropylamine (54714-49-7)

Guidance literature:

With hollandite; oxygen; In acetonitrile; at 80 ℃; for 4h; under 760.051 Torr; regioselective reaction;

DOI:10.1002/cctc.201300477

Reference yield:

diisopropylamine (108-18-9) + cyanomethyl bromide (590-17-0) → N-cyanomethyl-N,N-diisopropylamine (54714-49-7)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 5h;

DOI:10.1021/ja034502z

upstream raw materials:

N,N-diisopropylmethylamine

sodium cyanide

formaldehyd

potassium cyanide

Downstream raw materials:

N',N'-diisopropyl-ethane-1,2-diamine

N,N-diisopropyl-2-cyanothioacetamide

Refernces

• 1、 Suzuki, Kosuke,Tang, Fei,Kikukawa, Yuji,Yamaguchi, Kazuya,Mizuno, Noritaka. "Visible-light-induced photoredox catalysis with a tetracerium-containing silicotungstate". supporting information. p. 5356 - 5360. Retrieved 2014/06/09.
• 2、 Oka, Natsuhisa,Wada, Takeshi,Saigo, Kazuhiko. "An oxazaphospholidine approach for the stereocontrolled synthesis of oligonucleoside phosphorothioates". . p. 8307 - 8317. Retrieved 2007/10/03.