9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)-

Base Information

• Chemical Name: 9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)-
• CAS No.: 182438-97-7
• Molecular Formula: C18H17BrO2
• Molecular Weight: 345.23000
• Mol file: 182438-97-7.mol

Synonyms:9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)-;

Chemical Property of 9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)-

Chemical Property:

• PSA: 37.30000
• LogP: 4.60290

Purity/Quality:

98% ^*data from raw suppliers

9-(4-Bromobutyl)-9H-fluorene-9-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)-

There total 2 articles about 9H-Fluorene-9-carboxylic acid, 9-(4-bromobutyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1,4-dibromo-butane (110-52-1) + 9H-fluorene-9-carboxylic acid (1989-33-9) → 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid (182438-97-7)

Guidance literature:

9H-fluorene-9-carboxylic acid; With n-butyllithium; In tetrahydrofuran; at 0 ℃; for 1h;

1,4-dibromo-butane; In tetrahydrofuran; at 0 - 20 ℃; for 30.5h; Further stages.;

DOI:10.1021/jm000494a

Reference yield:

1,1-dibromobutane (62168-25-6) + 9H-fluorene-9-carboxylic acid (1989-33-9) → 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid (182438-97-7)

Guidance literature:

With hydrogenchloride; n-butyllithium; In tetrahydrofuran; hexane; water;

Reference yield: 76.1%

2,2,2-trifluroethylamine hydrochloride (373-88-6) + 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid (182438-97-7) → 9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoro-ethyl)-amide (182438-98-8)

Guidance literature:

9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid; With oxalyl dichloride; In dichloromethane; at 25 ℃; for 2h; Inert atmosphere;

2,2,2-trifluroethylamine hydrochloride; With triethylamine; In dichloromethane; at 25 ℃; for 2h;

upstream raw materials:

1,4-dibromo-butane

9H-fluorene-9-carboxylic acid

1,1-dibromobutane

Downstream raw materials:

9-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoro-ethyl)-amide

(2-oxo-2-{4-[9-(2,2,2-trifluoro-ethylcarbamoyl)-9H-fluoren-9-yl]-butyl}-2λ⁵-[1,3,2]dioxaphosphinan-5-yl)-carbamic acid benzyl ester

Refernces

• 1、 -. "AMORPHOUS FORM OF LOMITAPIDE MESYLATE". Paragraph 0123. . Retrieved 2016/05/02.
• 2、 -. "CONFORMATIONALLY RESTRICTED AROMATIC INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND METHOD". Page 144-145; 314. . Retrieved 2010/02/06.