3-METHYLHEXANEDIOIC ACID

Base Information

• Chemical Name: 3-METHYLHEXANEDIOIC ACID
• CAS No.: 61898-58-6
• Molecular Formula: C7H12O4
• Molecular Weight: 160.17
• Mol file: 61898-58-6.mol

Synonyms:2-menthene;(R)-p-menth-3-ene;4-methyl-1-isopropylcyclohexene;Δ3-menthene;(R)-menth-3-ene;(1R)-menth-3-ene;

Chemical Property of 3-METHYLHEXANEDIOIC ACID

Chemical Property:

• PSA: 74.60000
• LogP: 0.96200

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-METHYLHEXANEDIOIC ACID

There total 1 articles about 3-METHYLHEXANEDIOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-hydroxy-4-methylhexanoic acid (56493-06-2) → (R)-3-methylhexanedioic acid (623-82-5) + (-)-(S)-3-methylhexanedioic acid (61898-58-6)

Guidance literature:

With Jones reagent; In acetone; at 20 ℃; for 24h;

DOI:10.1021/ja309262f

Reference yield:

(-)-(S)-3-methylhexanedioic acid (61898-58-6) → (6S)-N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride (1321624-39-8)

Guidance literature:

Multi-step reaction with 5 steps

1: sulfuric acid / 8 h / Reflux

2: sodium / toluene / 3 h / Reflux

3: potassium tert-butylate / tert-butyl alcohol / Reflux

4: trichlorophosphate / 3 h / Reflux

5: hydrogenchloride / water; isopropyl alcohol / Reflux

With hydrogenchloride; sulfuric acid; potassium tert-butylate; sodium; trichlorophosphate; In water; isopropyl alcohol; toluene; tert-butyl alcohol; 2: Dieckmann condensation;

DOI:10.1021/jm2007722

upstream raw materials:

6-hydroxy-4-methylhexanoic acid

Downstream raw materials:

(6S)-N-(4-methoxyphenyl)-N,2,6-trimethyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-aminium chloride

Refernces