4-(Benzyloxy)-2-chloropyridine

Base Information

• Chemical Name: 4-(Benzyloxy)-2-chloropyridine
• CAS No.: 182556-72-5
• Molecular Formula: C12H10ClNO
• Molecular Weight: 219.671
• Hs Code.: 2933399090
• European Community (EC) Number: 848-822-6
• DSSTox Substance ID: DTXSID70695341
• Wikidata: Q82624493
• Mol file: 182556-72-5.mol

Synonyms:4-(BENZYLOXY)-2-CHLOROPYRIDINE;182556-72-5;2-chloro-4-phenylmethoxypyridine;MFCD11847315;2-chloro-4-benzyloxypyridine;SCHEMBL190551;DTXSID70695341;XZLZQERVHJHMAL-UHFFFAOYSA-N;AKOS013088651;AB10213;MB10107;AS-44450;SY195947;CS-0180893;EN300-97989

Chemical Property of 4-(Benzyloxy)-2-chloropyridine

Chemical Property:

• Boiling Point: 345.3±27.0 °C(Predicted)
• PKA: 2.19±0.10(Predicted)
• PSA: 22.12000
• Density: 1.225±0.06 g/cm3(Predicted)
• LogP: 3.31400
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 219.0450916
• Heavy Atom Count: 15
• Complexity: 183

Purity/Quality:

99%min ^*data from raw suppliers

4-(benzyloxy)-2-chloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC2=CC(=NC=C2)Cl

Technology Process of 4-(Benzyloxy)-2-chloropyridine

There total 4 articles about 4-(Benzyloxy)-2-chloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-chloro-4-nitropyridine (23056-36-2) + benzyl alcohol (100-51-6,185532-71-2) → 2-chloro-4-(benzyloxy)pyridine (182556-72-5)

Guidance literature:

benzyl alcohol; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 1h;

2-chloro-4-nitropyridine; In tetrahydrofuran; at 0 ℃; for 2h;

Reference yield: 52.0%

2,4-dichloropyridine (26452-80-2) + benzyl alcohol (100-51-6,185532-71-2) → 2-chloro-4-(benzyloxy)pyridine (182556-72-5)

Guidance literature:

benzyl alcohol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h; Inert atmosphere;

2,4-dichloropyridine; In N,N-dimethyl-formamide; mineral oil; Inert atmosphere;

Reference yield: 47.1%

4-(benzyloxy)pyridin-2(1H)-one (53937-02-3) → 2-chloro-4-(benzyloxy)pyridine (182556-72-5)

Guidance literature:

4-(benzyloxy)pyridin-2(1H)-one; With trichlorophosphate; at 90 ℃;

With sodium hydroxide; sodium carbonate; In water; pH=7;

upstream raw materials:

4-(benzyloxy)pyridin-2(1H)-one

2-chloro-4-nitropyridine

benzyl alcohol

2,4-dichloropyridine

Downstream raw materials:

4-(benzyloxy)pyridin-2-amine

4-(benzyloxy)-N-(4-methylthiazol-2-yl)pyridin-2-amine

4-(benzyloxy)-5-bromopyridin-2-amine

1-(4-(benzyloxy)-5-bromopyridin-2-yl)thiourea

Refernces

• 1、 -. "BENZIMIDAZOLE DERIVATIVES AND AZA-BENZIMIDAZOLE DERIVATIVES AS JANUS KINASE 2 INHIBITORS AND USES THEREOF". Paragraph 00225-00226. . Retrieved 2020/06/01.
• 2、 -. "NOVEL MONOCYCLIC AND BICYCLIC RING SYSTEM SUBSTITUTED CARBANUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS". Page/Page column 114. . Retrieved 2018/04/21.