(+/-)-BMS 204352

Base Information

• Chemical Name: (+/-)-BMS 204352
• CAS No.: 183720-28-7
• Molecular Formula: C16H10ClF4NO2
• Molecular Weight: 359.708
• Mol file: 183720-28-7.mol

Synonyms:3-(5-chloro-2-methoxy-phenyl)-3-fluoro-6-trifluoromethyl-1,3-dihydro-indol-2-one;(+/-)-5,7-dioxobicyclo<2.2.2>oct-2-ene;3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-indol-2-one;Bicyclo<2.2.2>oct-7-en-2,5-dion;(+/-)-bicyclo<2.2.2>oct-7-ene-2,5-dione;(+-)-3-(5-Chloro-2-methoxyphenyl)-1,3-dihydro-3-fluoro-6-(trifluoromethyl)2H-indol-2-one;Bicyclo[2.2.2]oct-2-ene-5,7-dione;

Chemical Property of (+/-)-BMS 204352

Chemical Property:

• Boiling Point: 436.9±45.0 °C(Predicted)
• PKA: 10.43±0.40(Predicted)
• PSA: 41.82000
• Density: 1.50±0.1 g/cm3(Predicted)
• LogP: 4.61770

Purity/Quality:

98% ^*data from raw suppliers

rac-BMS204352 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (+/-)-BMS 204352

There total 11 articles about (+/-)-BMS 204352 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

→ 3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-indol-2-one (183720-28-7,187523-36-0)

Guidance literature:

Reference yield: 81.0%

1-benzyl-3-(5-chloro-2-methoxyphenyl)-3-fluoro-6-(trifluoromethyl)indolin-2-one → 3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-indol-2-one (183720-28-7,187523-36-0)

Guidance literature:

With trifluoroacetic acid; at 60 ℃; for 16h; Inert atmosphere;

Reference yield: 73.0%

5-chloro-α-fluoro-2-methoxy-α-[2-nitro-4-(trifluoromethyl)-phenyl]benzeneacetic acid,methyl ester (206194-00-5) → 3-(5-Chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-indol-2-one (183720-28-7,187523-36-0)

Guidance literature:

5-chloro-α-fluoro-2-methoxy-α-[2-nitro-4-(trifluoromethyl)-phenyl]benzeneacetic acid,methyl ester; With sodium dithionite; tetrabutyl-ammonium chloride; In tetrahydrofuran; water; at 60 ℃; for 1.33333h;

In methanol; ethyl acetate; at 55 ℃;

upstream raw materials:

5-chloro-α-fluoro-2-methoxy-α-[2-nitro-4-(trifluoromethyl)-phenyl]benzeneacetic acid,methyl ester

1-fluoro-2-nitro-4-trifluoromethyl-benzene

5-chloro-2-methoxyphenylacetic acid,methyl ester

methyl 2-(5-chloro-2-methoxyphenyl)-2-(2-nitro-4-(trifluoromethyl)phenyl)acetate

Downstream raw materials:

(-)-BMS-204352

(S)-(+)-3-(5-chloro-2-methoxyphenyl)-3-fluoro-1,3-dihydro-6-(trifluoromethyl)-2H-indol-2-one

3-(5-chloro-2-methoxy-phenyl)-3-fluoro-1-methylsulfanylmethyl-6-trifluoromethyl-1,3-dihydro-indol-2-one

Refernces

• 1、 Mizuta, Satoshi,Otaki, Hiroki,Kitagawa, Ayako,Kitamura, Kanami,Morii, Yuki,Ishihara, Jun,Nishi, Kodai,Hashimoto, Ryo,Usui, Toshiya,Chiba, Kenya. "Ionic Liquid-Mediated Hydrofluorination of o-Azaxylylenes Derived from 3-Bromooxindoles". . p. 2572 - 2575. Retrieved 2017/05/24.
• 2、 -. "Use of 3-substituted oxindole derivatives as kcnq potassium channel modulators". . . Retrieved 2008/06/13.