ethyl methyl methylphosphonate

Base Information

• Chemical Name: ethyl methyl methylphosphonate
• CAS No.: 18755-36-7
• Molecular Formula: C4H11O3P
• Molecular Weight: 138.103
• Mol file: 18755-36-7.mol

Synonyms:

Chemical Property of ethyl methyl methylphosphonate

Chemical Property:

• Vapor Pressure: 2.77mmHg at 25°C

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl methyl methylphosphonate

There total 12 articles about ethyl methyl methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl-phosphonothioic acid O-ethyl ester S-(4-methoxy-phenyl) ester (886227-42-5) + sodium methylate (124-41-4) → 4-Methoxybenzenethiol (696-63-9) + O-ethyl O-methyl methylphosphonate (18755-36-7)

Guidance literature:

With N-ethylmorpholine;; perchloric acid; sodium methylate; La(OTf); In methanol; Title compound not separated from byproducts;

DOI:10.1002/anie.200503182

Reference yield:

methyl-phosphonothioic acid O-ethyl ester S-(4-fluoro-phenyl) ester (886227-41-4) + sodium methylate (124-41-4) → 4-Fluorothiophenol (371-42-6) + O-ethyl O-methyl methylphosphonate (18755-36-7)

Guidance literature:

With N-ethylmorpholine;; perchloric acid; sodium methylate; La(OTf); In methanol; Title compound not separated from byproducts;

DOI:10.1002/anie.200503182

Reference yield:

ethyl acetate (141-78-6) + dimethyl methane phosphonate (756-79-6) → O-ethyl O-methyl methylphosphonate (18755-36-7) + Diethyl methylphosphonate (683-08-9)

Guidance literature:

With potassium tert-butylate; for 0.00138889h; Yield given; Yields of byproduct given;

DOI:10.1021/jo9820521

upstream raw materials:

Diethyl methylphosphonate

methyl p-toluene sulfonate

ethyl ester of p-toluenesulfonic acid

dimethyl methane phosphonate

Refernces

• 1、 Gershonov,Columbus,Zafrani. "Facile hydrolysis-based chemical destruction of the warfare agents VX, GB, and HD by alumina-supported fluoride reagents". supporting information; experimental part. p. 329 - 338. Retrieved 2009/04/10.
• 2、 Kissling, Rebecca M.,Gagne, Michel R.. "Alkali metal alkoxide clusters: Convenient catalysts for the synthesis of methylphosphonates". . p. 1585 - 1590. Retrieved 2007/10/03.