Zinc, bromomethyl-

Base Information

• Chemical Name: Zinc, bromomethyl-
• CAS No.: 18815-74-2
• Molecular Formula: CH3BrZn
• Molecular Weight: 160.329
• Mol file: 18815-74-2.mol

Synonyms:Methyl-Zn-bromide;methylzinc bromide;methylzincbromide;

Chemical Property of Zinc, bromomethyl-

Chemical Property:

• PSA: 0.00000
• LogP: 1.42690

Purity/Quality:

99% ^*data from raw suppliers

MethylzincBromide(0.5MinTHF) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methylzinc Bromide is a useful reactant in organic synthesis.

Technology Process of Zinc, bromomethyl-

There total 6 articles about Zinc, bromomethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methylmagnesium bromide (75-16-1) + zinc dibromide (7699-45-8) → zinc methyl bromide (18815-74-2)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1055/s-0036-1591488

Reference yield:

methylmagnesium bromide (75-16-1) + zinc(II) chloride (7646-85-7,24359-56-6) → zinc methyl bromide (18815-74-2)

Guidance literature:

In tetrahydrofuran; diethyl ether;

Reference yield:

methyl bromide (74-83-9) + zinc (7440-66-6) → zinc methyl bromide (18815-74-2)

Guidance literature:

With iodine; In N,N-dimethyl acetamide; at 70 ℃; for 12h; Schlenk technique;

DOI:10.1021/acs.organomet.1c00112

upstream raw materials:

methylmagnesium bromide

zinc(II) chloride

dimethyl zinc(II)

zinc dibromide

Downstream raw materials:

9-(2-deoxy-3,5-di-O-p-toluoyl-β-D-erythro-pentofuranosyl)-6-methylpurine

3-Methylbutenoic acid

3-methylbut-3-enoic acid

(Z)-3,4-dimethyl-5-pentylidenefuran-2(5H)-one

Refernces

• 1、 Xu, Yan,Yi, Hong,Oestreich, Martin. "Enantioconvergent and Regioselective Synthesis of Allenylsilanes by Nickel-Catalyzed C(sp2)-C(sp3) Cross-Coupling Starting from Racemic α-Silylated Propargylic Bromides". supporting information. p. 2194 - 2197. Retrieved 2021/05/07.
• 2、 Nagy, Edith,Liu, Ying,Prentice, Kacey J.,Sloop, Kyle W.,Sanders, Phillip E.,Batchuluun, Battsetseg,Hammond, Craig D.,Wheeler, Michael B.,Durham, Timothy B.. "Synthesis and Characterization of Urofuranoic Acids: In Vivo Metabolism of 2-(2-Carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic Acid (CMPF) and Effects on in Vitro Insulin Secretion". . p. 1860 - 1875. Retrieved 2017/03/17.