2-Amino-5-methoxybenzamide

Base Information

• Chemical Name: 2-Amino-5-methoxybenzamide
• CAS No.: 1882-71-9
• Molecular Formula: C8H10N2O2
• Molecular Weight: 166.18
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID50605660
• Nikkaji Number: J3.440.173J
• Wikidata: Q82503981
• Mol file: 1882-71-9.mol

Synonyms:2-Amino-5-methoxybenzamide;1882-71-9;Benzamide, 2-amino-5-methoxy-;MFCD12674808;5-methoxyanthranilamide;5-methoxy-2-aminobenzamide;2-amino-5-methoxy-benzamide;SCHEMBL258365;2-amino-5-(methyloxy)benzamide;DTXSID50605660;NWZIAOBMRQYTTD-UHFFFAOYSA-N;BCP12915;AKOS010180070;AM62625;CS-W003834;GS-3908;AC-23542;SY013394;DB-065637;W-200607

Chemical Property of 2-Amino-5-methoxybenzamide

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Melting Point: 157-158 °C
• Boiling Point: 294.4oC at 760 mmHg
• PKA: 15.58±0.50(Predicted)
• Flash Point: 150.682oC
• PSA: 78.34000
• Density: 1.236g/cm3
• LogP: 1.65780
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 166.074227566
• Heavy Atom Count: 12
• Complexity: 172

Purity/Quality:

99%+, ^*data from raw suppliers

2-Amino-5-methoxybenzamide ^*data from reagent suppliers

Safty Information:

• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)N)C(=O)N

Technology Process of 2-Amino-5-methoxybenzamide

There total 14 articles about 2-Amino-5-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-nitro-5-methoxybenzamide (41994-92-7) → 2-amino-5-methoxybenzamide (1882-71-9)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 6h; under 760.051 Torr;

Reference yield: 90.0%

→ 2-amino-5-methoxybenzamide (1882-71-9)

Guidance literature:

Reference yield: 88.0%

5-methoxyisatine (39755-95-8) → 2-amino-5-methoxybenzamide (1882-71-9)

Guidance literature:

With ammonium hydroxide; dihydrogen peroxide; In dimethyl sulfoxide; at 20 - 30 ℃; for 4h; Sealed tube;

DOI:10.1016/j.tet.2019.01.067

upstream raw materials:

5-methoxy-2-nitro-benzoic acid

2-nitro-5-methoxybenzonitrile

5,5'-dimethoxy-2,2'-azoxy-di-benzoic acid diamide

2-nitro-5-methoxybenzamide

Downstream raw materials:

2-Amino-5-methoxybenzoic acid

6-Methoxyquinazolin-4-one

2-(3'-Methoxyphenyl)-6-methoxy-4-quinazolinone

5-methoxy-2-(3-nitrobenzoylamino)benzamide

Refernces

• 1、 Hour,Lee,Chen,Lee,Zhao,Lee. "Molecular modelling, synthesis, cytotoxicity and anti-tumour mechanisms of 2-aryl-6-substituted quinazolinones as dual-targeted anti-cancer agents". . p. 1574 - 1586. Retrieved 2013.
• 2、 Chen, Juncheng,Chiang, Cheng-Ming,He, Gu,Liu, Bo,Liu, Jie,Ouyang, Liang,Tang, Pan,Wang, Guan,Yang, Chengcan,Ye, Tinghong,Zhang, Jifa,Zhang, Jin,Zou, Ling. "Discovery of Novel Dual-Target Inhibitor of Bromodomain-Containing Protein 4/Casein Kinase 2 Inducing Apoptosis and Autophagy-Associated Cell Death for Triple-Negative Breast Cancer Therapy". . p. 18025 - 18053. Retrieved 2022/01/03.
• 3、 Chen, Xiulei,Zhou, Zhen,Li, Zhong,Xu, Xiaoyong. "Synthesis and nematicidal activities of 1,2,3-benzotriazin-4-one containing 4,5-dihydrothiazole-2-thiol derivatives against Meloidogyne incognita". . p. 194 - 200. Retrieved 2019/09/13.