Aziridine, 2-methylene-1-(phenylmethyl)-

Base Information

• Chemical Name: Aziridine, 2-methylene-1-(phenylmethyl)-
• CAS No.: 188818-06-6
• Molecular Formula: C10H11N
• Molecular Weight: 145.204
• Mol file: 188818-06-6.mol

Synonyms:

Chemical Property of Aziridine, 2-methylene-1-(phenylmethyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Aziridine, 2-methylene-1-(phenylmethyl)-

There total 9 articles about Aziridine, 2-methylene-1-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

potassium tert-butylate (865-47-4) + N-benzyl-2-(bromomethyl)aziridine (25662-24-2) → 4-methyl-1-phenyl-2-aza-1,3-butadiene (31201-91-9) + N-benzyl-2-methylene-aziridine (188818-06-6) + 1-benzyl-2-(tert-butoxymethyl)aziridine

Guidance literature:

In tetrahydrofuran; for 24h; Product distribution; Ambient temperature; other solvent, temperature, reaction time;

DOI:10.1021/jo962351v

Reference yield: 38.0%

N-(2-bromoallyl)benzylamine (72551-10-1) → N-propargylbenzylamine (1197-51-9) + N-benzyl-2-methylene-aziridine (188818-06-6)

Guidance literature:

With sodium amide; In ammonia; for 0.25h;

DOI:10.1039/b002223n

Reference yield: 20.0%

potassium tert-butylate (865-47-4) + N-benzyl-2-(bromomethyl)aziridine (25662-24-2) → N-benzyl-2-methylene-aziridine (188818-06-6) + 1-benzyl-2-(tert-butoxymethyl)aziridine

Guidance literature:

In tert-butyl alcohol; for 3h; Heating;

DOI:10.1021/jo962351v

upstream raw materials:

potassium tert-butylate

N-benzyl-2-(bromomethyl)aziridine

potassium 2-methylbutan-2-olate

N-(2-bromoallyl)benzylamine

Downstream raw materials:

dimethyl 2-((1-benzyl-4,5-dimethyl-1H-pyrrol-3-yl)methyl)-2-(but-2-yn-1-yl)malonate

1-benzyl-4-(hex-4-yn-1-yl)-2,3-dimethyl-1H-pyrrole

diethyl 2-((1-benzyl-4,5-dimethyl-1H-pyrrol-3-yl)methyl)-2-(but-2-yn-1-yl)malonate

dibenzyl 2-((1-benzyl-4,5-dimethyl-1H-pyrrol-3-yl)methyl)-2-(but-2-yn-1-yl)malonate

Refernces

• 1、 Ennis, David S.,Ince, Julie,Rahman, Sabitur,Shipman, Michael. "Observations on the ring opening reactions of 2-methyleneaziridines with acid chlorides and alkyl chloroformates". . p. 2047 - 2053. Retrieved 2007/10/03.