3-chloro-2-nitrobenzoyl chloride

Base Information

• Chemical Name: 3-chloro-2-nitrobenzoyl chloride
• CAS No.: 19088-99-4
• Molecular Formula: C7H3Cl2NO3
• Molecular Weight: 220.012
• Hs Code.: 2916399090
• Mol file: 19088-99-4.mol

Synonyms:2-Nitro-3-bromthieno<2,3-b>pyridin;2-Nitro-3-chlor-benzoylchlorid;3-Chloro-2-nitrobenzoylchlorid;3-Brom-2-nitrothieno<2,3-b>pyridin;3-Chlor-2-nitro-benzoylchlorid;

Chemical Property of 3-chloro-2-nitrobenzoyl chloride

Chemical Property:

• Melting Point: 50-56 °C
• Boiling Point: 316.9±22.0 °C(Predicted)
• PSA: 62.89000
• Density: 1.575±0.06 g/cm3(Predicted)
• LogP: 3.15040

Purity/Quality:

3-Chloro-2-nitrobenzoylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-chloro-2-nitrobenzoyl chloride

There total 2 articles about 3-chloro-2-nitrobenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

3-chloro-2-nitro-benzoic acid (4771-47-5) → 3-chloro-2-nitrobenzoyl chloride (19088-99-4)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 2h; Reflux; Inert atmosphere;

Reference yield:

→ 3-chloro-2-nitrobenzoyl chloride (19088-99-4)

Guidance literature:

Entspr. Saeure, PCl5;

Reference yield: 96.0%

3-chloro-2-nitrobenzoyl chloride (19088-99-4) → 3-chloro-2-nitrobenzamide (59772-47-3)

Guidance literature:

With ammonium hydroxide; for 0.333333h;

DOI:10.1021/jm00101a024

upstream raw materials:

3-chloro-2-nitro-benzoic acid

Downstream raw materials:

3-chloro-2-nitrobenzamide

3-chloro-N-(4-chloro-phenyl)-2-nitro-benzamide

2-(3-chloro-2-nitrophenyl)-4-methyl-1H-benzimidazole

(3-chloro-2-nitrophenyl)methanol

Refernces

• 1、 Chen, Yuepeng,Liu, Xinglei,Shi, Wei,Zheng, Shilong,Wang, Guangdi,He, Ling. "One-Pot Synthesis of Seven-Membered Heterocyclic Derivatives of Diazepines Involving Copper-Catalyzed Rearrangement Cascade Allyl-Amination". . p. 5146 - 5157. Retrieved 2020/05/19.
• 2、 Caraballo, Rémi,Larsson, Mikael,Nilsson, Stefan K.,Ericsson, Madelene,Qian, Weixing,Tran, Nam Phuong Nguyen,Kindahl, Tomas,Svensson, Richard,Saar, Valeria,Artursson, Per,Olivecrona, Gunilla,Enquist, Per-Anders,Elofsson, Mikael. "Structure-activity relationships for lipoprotein lipase agonists that lower plasma triglycerides in vivo". . p. 191 - 209. Retrieved 2015/09/15.