4-{Methyl(phenylmethyl)amino}-2,6-dibromo pyridine

Base Information

• Chemical Name: 4-{Methyl(phenylmethyl)amino}-2,6-dibromo pyridine
• CAS No.: 192447-61-3
• Molecular Formula: C13H12Br2N2
• Molecular Weight: 356.06
• DSSTox Substance ID: DTXSID801219438
• Mol file: 192447-61-3.mol

Synonyms:4-{methyl(phenylmethyl)amino}-2,6-dibromo pyridine;SCHEMBL7052975;GFTBHYJWKKZBPQ-UHFFFAOYSA-N;DTXSID801219438;192447-61-3;2,6-Dibromo-N-methyl-N-(phenylmethyl)-4-pyridinamine

Chemical Property of 4-{Methyl(phenylmethyl)amino}-2,6-dibromo pyridine

Chemical Property:

• XLogP3: 4.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 355.93467
• Heavy Atom Count: 17
• Complexity: 222

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN(CC1=CC=CC=C1)C2=CC(=NC(=C2)Br)Br

Technology Process of 4-{Methyl(phenylmethyl)amino}-2,6-dibromo pyridine

There total 4 articles about 4-{Methyl(phenylmethyl)amino}-2,6-dibromo pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(2,6-dibromo-4-pyridin-4-yl)-methylamine (193074-42-9) + benzyl bromide (100-39-0) → 4-{methyl(phenylmethyl)amino}-2,6-dibromo pyridine (192447-61-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield: 32.0%

benzyl-methyl-amine (103-67-3) + 2,6-dibromo-4-nitropyridine (175422-04-5) → 4-{methyl(phenylmethyl)amino}-2,6-dibromo pyridine (192447-61-3)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

DOI:10.1016/j.tetlet.2006.10.159

Reference yield:

(2,6-dibromo-4-pyridin-4-yl)-methylamine (193074-42-9) + benzyl bromide (100-39-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-{methyl(phenylmethyl)amino}-2,6-dibromo pyridine (192447-61-3)

Guidance literature:

In tetrahydrofuran; mineral oil;

upstream raw materials:

benzyl-methyl-amine

2,6-dibromo-4-nitropyridine

2,6-dibromo-4-nitro-pyridine 1-oxide

(2,6-dibromo-4-pyridin-4-yl)-methylamine

Downstream raw materials:

2-bromo-4-{methyl(phenylmethyl)-amino}-6-{3-(trifluoromethyl)phenoxy} pyridine

Refernces

• 1、 -. "N-(unsubstituted or substituted)-4-substituted-6-(unsubstituted or substituted)phenoxy-2-pyridinecarboxamides or thiocarboxamides, processes for producing the same, and herbicides". Example 4. . Retrieved 2010/01/30.