3-Ethylpiperidine

Base Information

• Chemical Name: 3-Ethylpiperidine
• CAS No.: 13603-10-6
• Molecular Formula: C7H15N
• Molecular Weight: 113.203
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90929231
• Nikkaji Number: J50.664H
• Mol file: 13603-10-6.mol

Synonyms:3-Ethylpiperidine;13603-10-6;Piperidine, 3-ethyl-;3-Ethyl-piperidine;beta-Aethylpiperidin;beta-Aethylpiperidin [German];SCHEMBL893651;DTXSID90929231;MFCD01700577;AKOS008121559;SB42869;BS-12870;LS-115516;BB 0261280;CS-0216233;FT-0681576;EN300-36982;N10050;Z381019246

Chemical Property of 3-Ethylpiperidine

Chemical Property:

• Vapor Pressure: 3.47mmHg at 25°C
• Melting Point: 149 °C
• Refractive Index: 1.423
• Boiling Point: 152.6 °C at 760 mmHg
• PKA: 10.49±0.10(Predicted)
• Flash Point: 33.8 °C
• PSA: 12.03000
• Density: 0.808 g/cm³
• LogP: 1.72480
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 113.120449483
• Heavy Atom Count: 8
• Complexity: 61.4

Purity/Quality:

99% ^*data from raw suppliers

3-Ethylpiperidine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCC1CCCNC1

Technology Process of 3-Ethylpiperidine

There total 14 articles about 3-Ethylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-ethylpyridine (536-78-7,151103-56-9) → (+/–)-3-ethylpiperidine (13603-10-6)

Guidance literature:

With hydrogen; platinum(IV) oxide; In acetic acid; at 20 ℃; under 1551.49 - 3102.97 Torr;

DOI:10.1039/b209165h

Reference yield: 72.0%

2-bromo-3-(1,1-difluoroethyl)pyridine → 3-(1,1-difluoroethyl)piperidine + (+/–)-3-ethylpiperidine (13603-10-6)

Guidance literature:

2-bromo-3-(1,1-difluoroethyl)pyridine; With 5% Rh/C; hydrogen; In methanol; at 25 ℃; under 760.051 Torr;

With potassium hydroxide; In diethyl ether; water; at 25 ℃; for 0.25h; Reagent/catalyst; Solvent; Catalytic behavior;

DOI:10.1016/j.jfluchem.2019.05.006

Reference yield:

→ (+/–)-3-ethylpiperidine (13603-10-6)

Guidance literature:

With hydrogenchloride; platinum; Hydrogenation;

DOI:10.1021/ja01329a062

upstream raw materials:

3-ethylpyridine

ethanol

methyl-3-pyridylketone

hydrogenchloride

Downstream raw materials:

3-ethyl-1-(3-phenylprop-2-ynyl)piperidine

1-[3-(p-tert.butyl-phenyl)-2-methyl-2-propenyl]-3-ethyl-piperidine

C₃₅H₄₆N₄O₃

Refernces

• 1、 -. "NICOTINIC ACID DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS". Page/Page column 31. . Retrieved 2008/06/13.