Triamterene Related Compound B (50 mg) (2,7-diamino-4-hydroxy-6-phenylpteridine)

Base Information

• Chemical Name: Triamterene Related Compound B (50 mg) (2,7-diamino-4-hydroxy-6-phenylpteridine)
• CAS No.: 19375-89-4
• Molecular Formula: C12H10N6O
• Molecular Weight: 254.24700
• Hs Code.: 2933997500
• Mol file: 19375-89-4.mol

Synonyms:2,7-diamino-6-phenyl-1H-pteridin-4-one;Triamterene impurity B;Triamterene Related Compound B;

Chemical Property of Triamterene Related Compound B (50 mg) (2,7-diamino-4-hydroxy-6-phenylpteridine)

Chemical Property:

• Melting Point: >300°C
• PSA: 125.29000
• LogP: 0.81700
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly, Heated, Sonicated)

Purity/Quality:

98% ^*data from raw suppliers

2,7-Diamino-6-phenyl-4-pteridinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2,7-Diamino-6-phenyl-4-pteridinol has potential as a pteridine diuretic. Impurity in the synthesis of Triamterene (T767325), a weak diuretic with potassium sparing properties; blocks Na+ reuptake in the kidneys.

Technology Process of Triamterene Related Compound B (50 mg) (2,7-diamino-4-hydroxy-6-phenylpteridine)

There total 3 articles about Triamterene Related Compound B (50 mg) (2,7-diamino-4-hydroxy-6-phenylpteridine) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylacetonitrile (140-29-4) → 2,7-diamino-6-phenyl-3H-pteridin-4-one (19375-89-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium-<2-ethoxy ethylate>; 2-ethoxy-ethanol

2: aqueous HCl

With hydrogenchloride; 2-ethoxy-ethanol; sodium 2-ethoxyethoxide;

DOI:10.1039/jr9540002887

Reference yield:

2,6-diamino-5-nitroso-3H-pyrimidin-4-one (62128-61-4) + phenylacetonitrile (140-29-4) → 2,7-diamino-6-phenyl-3H-pteridin-4-one (19375-89-4)

Guidance literature:

With sodium 2-hydroxyethoxide; ethylene glycol;

DOI:10.1039/jr9540002887

Reference yield:

triamterene (396-01-0) → 2,7-diamino-6-phenyl-3H-pteridin-4-one (19375-89-4) + 2,4-diamino-6-phenyl-7(8H)-pteridinone (19152-93-3)

Guidance literature:

With hydrogenchloride;

DOI:10.1039/jr9540002887

upstream raw materials:

2,6-diamino-5-nitroso-3H-pyrimidin-4-one

phenylacetonitrile

triamterene