Methyl-5-(bromomethyl)pyrazine-2-carboxylate

Base Information

• Chemical Name: Methyl-5-(bromomethyl)pyrazine-2-carboxylate
• CAS No.: 193966-70-0
• Molecular Formula: C7H7BrN2O2
• Molecular Weight: 231.049
• Hs Code.: 2933990090
• Mol file: 193966-70-0.mol

Synonyms:5-bromomethyl-2-methoxy carbonyl pyrazine;Methyl-5-(bromomethyl)pyrazine-2-carboxylate;5-bromomethyl-pyrazine-2-carboxylic acid methyl ester;

Chemical Property of Methyl-5-(bromomethyl)pyrazine-2-carboxylate

Chemical Property:

• PSA: 52.08000
• LogP: 1.15810
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Methyl5-(Bromomethyl)pyrazine-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl-5-(bromomethyl)pyrazine-2-carboxylate

There total 7 articles about Methyl-5-(bromomethyl)pyrazine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.5%

methyl 5-(hydroxymethyl)pyrazine-2-carboxylate (1262803-64-4) → methyl 5-(bromomethyl)pyrazine-2-carboxylate (193966-70-0)

Guidance literature:

With N-Bromosuccinimide; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 1.5h;

Reference yield: 46.0%

5-methylpyrazine-2-carboxylic acid methyl ester (41110-33-2) → methyl 5-(bromomethyl)pyrazine-2-carboxylate (193966-70-0)

Guidance literature:

With bromine; acetic acid; at 80 ℃; for 1h; Concentration;

Reference yield: 26.0%

5-methylpyrazine-2-carboxylic acid methyl ester (41110-33-2) → methyl 5-(bromomethyl)pyrazine-2-carboxylate (193966-70-0) + 5-dibromomethyl-pyrazine-2-carboxylic acid methyl ester (866327-72-2)

Guidance literature:

With N-Bromosuccinimide; dibenzoyl peroxide; In tetrachloromethane; for 5h; Irradiation;

DOI:10.1021/jm020881f

upstream raw materials:

5-methylpyrazine-2-carboxylic acid methyl ester

2-methylpyrazin-5-carboxylic acid

azobisisobutyronitrile

methyl 5-(hydroxymethyl)pyrazine-2-carboxylate

Downstream raw materials:

5-{3-chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenoxymethyl}-pyrazine-2-carboxylic acid methyl ester

Refernces

• 1、 -. "TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A PYRIDINE OR PYRAZINE MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR". Paragraph 0139. . Retrieved 2019/02/28.
• 2、 -. "N-ARYLMETHYL SULFONAMIDE NEGATIVE MODULATORS OF NR2A". Paragraph 0138. . Retrieved 2015/04/15.