4-METHOXY-3'-TRIFLUOROMETHYLBIPHENYL

Base Information

• Chemical Name: 4-METHOXY-3'-TRIFLUOROMETHYLBIPHENYL
• CAS No.: 194873-98-8
• Molecular Formula: C14H11F3O
• Molecular Weight: 252.23200
• Hs Code.: 2909309090
• Mol file: 194873-98-8.mol

Synonyms:4-methoxy-3'-(trifluoromethyl)-1,1'-biphenyl;4-methoxy-3'-(trifluoromethyl)biphenyl;4-(3-trifluoromethylphenyl)anisole;4-methoxy-3-(trifluoromethyl)biphenyl;4-methoxy-3'-trifluoromethylbiphenyl;4'-methoxy-3-(trifluoromethyl)biphenyl;1,1'-Biphenyl, 4'-methoxy-3-(trifluoromethyl)-;

Chemical Property of 4-METHOXY-3'-TRIFLUOROMETHYLBIPHENYL

Chemical Property:

• PSA: 9.23000
• LogP: 4.38100

Purity/Quality:

95% ^*data from raw suppliers

4-METHOXY-3'-TRIFLUOROMETHYLBIPHENYL ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHOXY-3'-TRIFLUOROMETHYLBIPHENYL

There total 37 articles about 4-METHOXY-3'-TRIFLUOROMETHYLBIPHENYL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-methoxyphenylboronic acid (5720-07-0) + 3-chlorotrifluoromethylbenzene (98-15-7) → 4-(3-trifluoromethylphenyl)anisole (194873-98-8)

Guidance literature:

With potassium phosphate tribasic trihydrate; cis-[PdCl₂(Ph₂PNHpy)]; In N,N-dimethyl-formamide; at 100 ℃; for 15h; Schlenk technique;

DOI:10.1016/j.tet.2017.04.034

Reference yield: 95.0%

4-chloromethoxybenzene (623-12-1) + (meta-(trifluoromethyl)phenyl)boronic acid (1423-26-3) → 4-(3-trifluoromethylphenyl)anisole (194873-98-8)

Guidance literature:

With potassium phosphate; N,N'-bis-[2,4,6-tri(3,3,3-trifluoropropyl)phenyl]-4,5-dihydroimidazolium chloride; palladium diacetate; In tetrahydrofuran; water; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.tet.2012.05.068

Reference yield: 95.0%

3-(trifluoromethyl)phenyl 4-methylbenzenesulfonate (131086-40-3) + 4-methoxyphenyl magnesium bromide (13139-86-1) → 4-(3-trifluoromethylphenyl)anisole (194873-98-8)

Guidance literature:

With PinP(O)H; [Pd(dibenzylideneacetone)2]; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 22h;

DOI:10.1021/ol061116o

upstream raw materials:

para-iodoanisole

m-trifluoromethylphenyl iodide

1-bromo-4-methoxy-benzene

(meta-(trifluoromethyl)phenyl)boronic acid

Downstream raw materials:

3'-(trifluoromethyl)[1,1'-biphenyl]-4-ol

Refernces

• 1、 Nakamura, Tomoaki,Kinoshita, Hidenori,Shinokubo, Hiroshi,Oshima, Koichiro. "Biaryl Synthesis from Two Different Aryl Halides with Tri(2-furyl)germane". . p. 3165 - 3167. Retrieved 2002.
• 2、 Yi, Xiaowen,Chen, Kai,Guo, Junjun,Chen, Wei,Chen, Wanzhi. "Nickel(II)/N-Heterocyclic Carbene Catalyzed Desulfinylative Arylation by C?S Cleavage of Aryl Sulfoxides with Phenylboronic Acids". supporting information. p. 4373 - 4377. Retrieved 2020/07/27.
• 3、 Haensch, Veit G.,Neuwirth, Toni,Steinmetzer, Johannes,Kloss, Florian,Beckert, Rainer,Gr?fe, Stefanie,Kupfer, Stephan,Hertweck, Christian. "Metal-Free Aryl Cross-Coupling Directed by Traceless Linkers". . p. 16068 - 16073. Retrieved 2019/11/28.