O-BENZYL-L-SERINE METHYL ESTER HYDROCHLORIDE

Base Information

• Chemical Name: O-BENZYL-L-SERINE METHYL ESTER HYDROCHLORIDE
• CAS No.: 19525-87-2
• Molecular Formula: C11H15NO3.ClH
• Molecular Weight: 245.706
• Hs Code.: 2923900090
• Mol file: 19525-87-2.mol

Synonyms:O-Bn-L-Ser-OMe hydrochloride;Methyl O-Benzyl-L-serinate Hydrochloride;H-Ser(Bzl)-OMe·HCl;o-benzyl-l-serinemethylesterHCl;Benzylserinemethylesterhydrochloride;O-methyl O-benzyl-L-serinate hydrochloride;(S)-Methyl 2-amino-3-(benzyloxy)propanoate hydrochloride;O-Benzyl-L-serine Methyl Ester Hydrochloride;

Chemical Property of O-BENZYL-L-SERINE METHYL ESTER HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.000169mmHg at 25°C
• Melting Point: 164-166 °C
• Refractive Index: 5 ° (C=1, MeOH)
• Boiling Point: 330.2oC at 760 mmHg
• Flash Point: 146.7oC
• PSA: 61.55000
• Density: 1.126g/cm3
• LogP: 2.20580
• Storage Temp.: Store at 0°C
• Water Solubility.: almost transparency

Purity/Quality:

98%,99%, ^*data from raw suppliers

O-Benzyl-L-serine Methyl Ester Hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

Useful:

• Uses: O-Benzyl-L-serine Methyl Ester Hydrochloride is a reactant used in the synthesis of ureidopeptides and peptidyl ureas.

Technology Process of O-BENZYL-L-SERINE METHYL ESTER HYDROCHLORIDE

There total 5 articles about O-BENZYL-L-SERINE METHYL ESTER HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

BOC-O-benzyl-L-serine (23680-31-1) → O-methyl O-benzyl-L-serinate hydrochloride (19525-87-2)

Guidance literature:

With thionyl chloride; In dichloromethane; at 0 ℃; for 14h;

Reference yield: 100.0%

methanol (67-56-1) + O-Benzyl-L-serine (4726-96-9,32520-12-0) → O-methyl O-benzyl-L-serinate hydrochloride (19525-87-2)

Guidance literature:

With thionyl chloride; at 20 ℃; for 18h;

DOI:10.1016/j.tetasy.2008.06.030

Reference yield: 90.0%

methanol (67-56-1) + O-benzyl-L-serine hydrochloride (76614-98-7) → O-methyl O-benzyl-L-serinate hydrochloride (19525-87-2)

Guidance literature:

With hydrogenchloride; for 6h; Heating;

DOI:10.1016/j.tet.2006.05.010

upstream raw materials:

methanol

O-Benzyl-L-serine

O-benzyl-L-serine hydrochloride

BOC-O-benzyl-L-serine

Downstream raw materials:

methyl O-benzyl-N-(tert-butoxycarbonyl)-L-serinate

methyl (2S)-2-(N,N-dibenzylamino)-3-benzyloxypropanoate

H-Ile-Ser(Bzl)-OMe*TFA

Refernces

• 1、 Incerti, Matteo,Tognolini, Massimiliano,Russo, Simonetta,Pala, Daniele,Giorgio, Carmine,Hassan-Mohamed, Iftiin,Noberini, Roberta,Pasquale, Elena B.,Vicini, Paola,Piersanti, Silvia,Rivara, Silvia,Barocelli, Elisabetta,Mor, Marco,Lodola, Alessio. "Amino acid conjugates of lithocholic acid as antagonists of the EphA2 receptor". supporting information. p. 2936 - 2947. Retrieved 2013/05/22.
• 2、 -. "SUBSTITUTED AMINO-BENZIMIDAZOLES, MEDICAMENTS COMPRISING SAID COMPOUND, THEIR USE AND THEIR METHOD OF MANUFACTURE". Page/Page column 112-113. . Retrieved 2009/09/05.