2-ISOPROPYL-3,3-DIMETHYLBUTYRICACID

Base Information

• Chemical Name: 2-ISOPROPYL-3,3-DIMETHYLBUTYRICACID
• CAS No.: 3302-11-2
• Molecular Weight: 0
• Hs Code.: 2915900090
• Mol file: 3302-11-2.mol

Synonyms:2-ISOPROPYL-3,3-DIMETHYLBUTYRICACID

Chemical Property of 2-ISOPROPYL-3,3-DIMETHYLBUTYRICACID

Chemical Property:

• PSA: 37.30000
• LogP: 2.38930

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-ISOPROPYL-3,3-DIMETHYLBUTYRICACID

There total 11 articles about 2-ISOPROPYL-3,3-DIMETHYLBUTYRICACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Isopropyl-tert.-butylessigsaeure-triethylcarbinylester (88826-44-2) → Isopropyl-tert.-butyl-essigsaeure (3302-11-2)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; Heating;

Reference yield:

Potassium; 1-(1,1-diethyl-propoxy)-3,3-dimethyl-butan-1-olate → Isopropyl-tert.-butyl-essigsaeure (3302-11-2)

Guidance literature:

Multi-step reaction with 2 steps

1: liquid ammonia

2: aq. HCl / dioxane

With hydrogenchloride; In 1,4-dioxane; ammonia;

DOI:10.1021/ja00891a031

Reference yield:

2-iodo-propane (75-30-9) + dilithiated tert-butylacetic acid (66730-63-0) → Isopropyl-tert.-butyl-essigsaeure (3302-11-2)

Guidance literature:

dilithiated tert-butylacetic acid; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; In tetrahydrofuran; at 5 ℃; for 0.5h;

2-iodo-propane; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1021/jm901229s

upstream raw materials:

2-isopropyl-3,3-dimethylbutanamide

Isopropyl-tert.-butylessigsaeure-triethylcarbinylester

N-Isopropyl-tert.-butyl-isopropyl-acetamid

carbon monoxide

Downstream raw materials:

2-isopropyl-3,3-dimethylbutanamide

2-(1-isopropyl-2,2-dimethyl-propyl)-4,4-dimethyl-4,5-dihydro-oxazole

2-Isopropyl-3,3-dimethylbuttersaeuremethylester

Refernces

• 1、 Mawasi, Hafiz,Shekh-Ahmad, Tawfeeq,Finnell, Richard H.,Wlodarczyk, Bogdan J.,Bialer, Meir. "Pharmacodynamic and pharmacokinetic analysis of CNS-active constitutional isomers of valnoctamide and sec-butylpropylacetamide - Amide derivatives of valproic acid". . p. 72 - 78. Retrieved 2015.
• 2、 Kaufmann, Dan,Bialer, Meir,Shimshoni, Jakob Avi,Devor, Marshall,Yagen, Boris. "Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues". experimental part. p. 7236 - 7248. Retrieved 2010/07/04.